22 documents found, page 1 of 3
Natural Products from Marine Invertebrates and Microorganisms in Brazil between...
Ióca,Laura P.; Nicacio,Karen J.; Berlinck,Roberto G. S.The Brazilian marine biodiversity represents a unique, yet underexplored resource of biologically active compounds. This review provides an analysis of the development of marine natural products chemistry in Brazil within the period comprised between 2004 and 2017. Emphasis is directed towards marine invertebrate and marine microorganisms metabolites, including isolation, structure analysis, biosynthesis, bioac...
A QUÍMICA DE PRODUTOS NATURAIS DO BRASIL DO SÉCULO XXI
Berlinck,Roberto G. S.; Borges,Warley de S.; Scotti,Marcus T.; Vieira,Paulo C.The chemistry of natural products in Brazil has experienced a rapid development during the 21st century, with a diversification of lines of research, methodological approaches, exploration of diverse natural sources for the isolation of secondary metabolites and establishment of several multidisciplinary initiatives. These topics are critically discussed, evidencing achievements and new challenges to be faced f...
Evaluation of Chemical Defense and Chemical Diversity in the Exotic Bryozoan Am...
Santos,Larissa A. H. dos; Clavico,Etiene E. G.; Parra,Lizbeth L. L.; Berlinck,Roberto G. S.; Ferreira,Antonio G.; Paul,Valerie J.; Pereira,Renato C.The present investigation tests the effects against feeding by fishes of crude extracts obtained from eleven distinct populations of the bryozoan Amathia verticillata, an invasive species found globally in tropical to warm-temperate waters. Investigation of extracts from 11 populations of A. verticillata led to the identification and quantification of the known indole alkaloid 2,5,6-tribromo-N-methylgramine and...
A STRATEGY FOR THE RAPID IDENTIFICATION OF FUNGAL METABOLITES AND THE DISCOVERY...
Ióca,Laura P.; Romminger,Stelamar; Santos,Mario F. C.; Bandeira,Karin F.; Rodrigues,Fabiana T.; Kossuga,Miriam H.; Nicacio,Karen J.The isolation and identification of bioactive metabolites from complex extracts obtained from microbial growth media is a time consuming, costly, and labor-intensive task. A strategy to rapidly identify secondary metabolites isolated from extracts obtained from the culture media of marine-derived and endophytic fungal strains is described. Identification was achieved by HPLC-UV-MS and 1H NMR analyses in combina...
Rodriguesic acids, modified diketopiperazines from the gastropod mollusc Pleuro...
Pereira,Fabio R.; Santos,Mario F. C.; Williams,David E.; Andersen,Raymond J.; Padula,Vinicius; Ferreira,Antonio G.; Berlinck,Roberto G. S.In the present investigation, two specimens of the nudipleuran mollusc Pleurobranchus areolatus have shown to accumulate oxidized rodriguesin A derivatives. Rodriguesic acid presents a carboxylic acid replacing the terminal methyl group of the alkyl chain of rodriguesin A. A hydroxamate group was also present on the diketopiperazine moiety of a rodriguesic acid derivative. The structures of both rodriguesic aci...
Evaluating methods for the isolation of marine-derived fungal strains and produ...
Kossuga,Miriam H.; Romminger,Stelamar; Xavier,Camila; Milanetto,Marília C.; Valle,Milene Z. do; Pimenta,Eli F.; Morais,Raquel P.; Carvalho,Erica deIn the present investigation we evaluate methods for the isolation and growth of marine-derived fungal strains in artificial media for the production of secondary metabolites. Inoculation of marine macroorganisms fragments in Petri dishes proved to be the most convenient procedure for the isolation of the largest number of strains. Among the growth media used, 3% malt extract showed the best result for strains ...
Biosynthesis of two dihydropyrrole-polyketides from a marine-derived Penicilliu...
Romminger,Stelamar; Pimenta,Eli F.; Nascimento,Eduardo S.; Ferreira,Antonio G.; Berlinck,Roberto G. S.Feeding experiments with 13C-labeled precursors were performed in order to establish the biosynthesis of two N-acylated dihydropyrroles, (8E)-1-(2,3-dihydro-1H-pyrrol-1-yl)-2-methyldec8-ene-1,3-dione (1) and 1-(2,3-dihydro-1H-pyrrol-1-yl)-2-methyldecane-1,3-dione (2), isolated from the cultures of a marine-derived Penicillium citrinum. The biosynthesis of both, 1 and 2, involves the incorporation of acetate, me...
Utilização de detecção por espalhamento de luz evaporativo para a análise de pr...
Urano,Raquel P. Morais; Rodrigues,Fabiana T.; Berlinck,Roberto G. S.The interest in the use of evaporative light scattering detector (ELSD) for the analysis of different classes of natural products has grown over the years. This is because this detector has become an excellent alternative compared to other types of detectors, such as the refractive index detector and the ultraviolet (UV) detector. This review describes the basic principles of ELSD functioning and discusses the ...
Metabólitos secundários dos nudibrânquios Tambja stegosauriformis, Hypselodoris...
Pereira,Fábio R.; Berlinck,Roberto G. S.; Rodrigues Filho,Edson; Veloso,Katyuscya; Ferreira,Antonio G.; Padula,ViniciusThe chemical investigation of the MeOH extract from the bryozoan B. dentata MeOH yielded tambjamines A (1), C (3), D (4), K (6), aldehyde 8 and the new tambjamine J1(9), while the extract of its predator, the nudibranch Tambja stegosauriformis, yielded tambjamines C and K, along with aldehyde 8. Furodisinin lactone (11) was isolated from the nudibranch Hypselodoris lajensis, a compound previously isolated from ...
The academic plagiarism and its punishments - a review
Berlinck,Roberto G. S.Currently there is an increase in the occurrence of plagiarism in varied types of academic texts. Therefore, in agreement with the Brazilian Coordination of Improvement of Higher Education Personnel (CAPES) policies, Brazilian higher education institutions should establish guidelines for the detection and inhibition of academic plagiarism. However, the notion of plagiarism is extremely complex, since the abilit...