21 documents found, page 1 of 3

Eucalyptus-enhanced cotton: pretreatment and bioactive coating strategies for t...

Eucalyptus essential oils and extracts are widely recognized for their antimicrobial, antioxidant, insecticidal, anti-inflammatory, and aromatizing properties, making them highly valuable across pharmaceuticals, cosmetics, and textiles. For the design of biomedical textiles, cotton is favored for its mechanical strength, porosity, and biodegradability, but its vulnerability to microbial action limits its applic...

Silk fibroin microparticles as a candidate for wound healing applications: eval...

In this study, silk fibroin (SF) aerogel microparticles were developed as a delivery system for adenosine (ADO) to exploit its anti-inflammatory and regenerative properties for wound healing. Supercritical CO2 drying was used to prepare ADO-loaded SF aerogel microparticles with different SF concentrations (3 %, 5 %, 7 % w/v) and SF: ADO ratios (10:1, 5:1, 2:1). Characterization revealed high porosity (91–94 %),...

Dual and sequential drug delivery systems with antimicrobial and bone regenerat...

Bone defect healing is often compromised by infections acquired during surgery, hindering regeneration. An effective solution should first prevent infection and then promote bone repair. Localised drug-delivery systems capable of dual and sequential release of antimicrobial and bone-regenerative agents represent a promising solution; however, precisely controlling this sequential release remains an unmet challe...

Silk fibroin–alginate aerogel beads produced by supercritical CO2 drying: a dua...

Infection control and bleeding management in deep wounds remain urgent and unmet clinical challenges that demand innovative, multifunctional, and sustainable solutions. Unlike previously reported sodium alginate and silk fibroin-based gel formulations, the present work introduces a dual-functional system combining antimicrobial and haemostatic activity in the form of conformable aerogel beads. This dual-functio...

Expanding the potential of self-assembled silk fibroin as aerogel particles for...

A newly produced silk fibroin (SF) aerogel particulate system using a supercritical carbon dioxide (scCO2)-assisted drying technology is herein proposed for biomedical applications. Different concentrations of silk fibroin (3%, 5%, and 7% (w/v)) were explored to investigate the potential of this technology to produce size- and porosity-controlled particles. Laser diffraction, helium pycnometry, nitrogen adsorpt...

Adenosine-loaded silk fibroin: a promising approach for chronic wound healing a...

Introduction: Chronic wounds are one of the major therapeutic and healthcare challenges affecting the population globally. During the healing stage of a wound the production of exudate is considered as a normal process. However, its overproduction can compromise and delay the inflammatory phase, contributing to wound chronicity. Aerogels are highly porous materials which can provide advanced performance for wou...

Exploring new biobased material sources as platforms to advance skin wound heal...

Chronic wounds are one of the major therapeutic and healthcare challenges affecting the population globally. One of the research interests of the Biomaterials and Biomedical Technology Lab (BBT Lab) is to explore the potential of biobased material platforms to advance skin wound healing and regeneration solutions. From the use of natural based biopolymers such as silk fibroin (SF) or sulfated exopolysaccharides...

Sustainable silk-based particulate systems for the controlled release of pharma...

The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems in promoting the controlled release of pharmaceuticals and bioactive agents in the context of wound healing and skin regeneration. Silk fibroin and sericin are deriv...

Unleashing the healing potential of adenosine: advanced silk fibroin aerogel fo...

In vitro assessment of silk fibroin aerogel particles loaded with adenosine for...