Merosinopathy is a subtype of muscular dystrophy with recessive autosomal transmission, resulting from an α2-chain-laminin/merosin deficiency. It affects around 1-9/ 1 000 000 individuals. Classically, it is subdivided in two phenotypic categories: one that is more common and severe, known as congenital muscular dystrophy type 1A, and a lesser common form of mild presentation. Congenital muscular dystrophy type...
Introduction: Although scarce, regional telestroke networks have been developed worlwide in the last few decades. The COVID-19 pandemic put the healthcare system under exceptional pressure. We aimed to assess the impact of the first year of the COVID-19 pandemic on the telestroke network performance in the central region of mainland Portugal. Methods: Retrospective multicenter cohort study including the eight h...
Alzheimer’s disease (AD) heritability is estimated to be around 70–80%. Yet, much of it remains to be explained. Studying transmission patterns may help in understanding other factors contributing to the development of AD. In this study, we aimed to search for evidence of autosomal recessive or X- and Y-linked inheritance of risk factors in a large cohort of Portuguese AD patients. We collected family history f...
The existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two unique central nervous system vasculature features that result in an intimate relationship between neurons, glia, and blood vessels. This leads to a significant pathophysiological overlap between neurodegenerative and cerebrovascular diseases. Alzheimer's disease (AD) is the most prevalent neurodegenerative disease whose p...
Ageism refers to stereotyping (how we think), prejudice (how we feel), and discrimination (how we act) against people based on their age. It is a serious public health issue that can negatively impact older people’s health and quality of life. The present protocol has several goals: (1) adapt the Ambivalent Ageism Scale for the general Portuguese population and healthcare professionals; (2) assess the factorial...
In this work it was done a general review about HCAI and the knowledge that relates them with amoebas, in order to call attention to the fact that these protozoa could constitute a public health problem.
"There has been a successive advancement in the knowledge about exosomes, such as the discovery of genetic information in their composition, which created a new view on the medical applications of these extracellular vesicles and widened the range of their utility as therapeutic agents with capability to naturally transfer molecules locally as well as at the system level."
"The prostate cancer (PC) is one of the most frequent neoplasia in men even though not the deadliest. Every year more than 1,1 million men are diagnose with PC worldwide. The principal risks factors are: age, diet, familiar predisposition, race and hormones. Gleason classification is use to graduate PC based upon the histologic pattern of tumoral growth. Additionally to this classification is use TNM that allow...