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Incidental versus symptomatic nonfunctioning pituitary adenomas: Are they diffe...

Guerreiro, V; Mendonça, F; Ferreira, HU; Freitas, P; Pereira, J; Bernardes, I; Pinheiro, J; Guimarães, T; Carvalho, D

Background Nonfunctioning pituitary adenomas (NFPAs) constitute one of the most common tumours in the sellar region and are often discovered only when associated with compressive symptoms. With the frequent use of brain imaging, there has been an increase in the prevalence of incidentally discovered NFPAs.Aim We aim to determine the prevalence of incidental diagnosis with NPAs observed over a decade and compare...


Acromegaly with congenital generalized lipodystrophy - Two rare insulin resista...

Guerreiro, V; Bernardes, I; Pereira, J; Silva, RP; Fernandes, S; Carvalho, D; Freitas, P

Background: Lipodystrophies are a group of diseases which are characterized by abnormal adipose tissue deposition and are frequently associated with metabolic changes. Congenital generalized lipodystrophy is an autosomal recessive syndrome, with a prevalence < 1:10 million. Acromegaly is a rare disease, secondary to the chronic hypersecretion of growth hormone and insulin-like growth factor-1, with characterist...


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