5 documents found, page 1 of 1
Can the free/total psa ratio predict undetected intraductal carcinoma and cribr...
Bernardino, RM; Yin, LB; Lajkosz, K; Cockburn, JG; Wettstein, MS; Woon, D; Nguyen, DD; Sayyid, R; Leão, R; van der Kwast, T; Fleshner, NBackground: Intraductal carcinoma (IDC) and cribriform pattern (Crib) of prostate cancer are recognised as independent prognosticators of poor outcome, both in prostate biopsies and radical prostatectomy (RP) specimens. Objective: This study aimed to determine the predictive value of Free-to-total PSA ratio (FPSAR) in identifying missed IDC/Crib at the time of biopsy as compared to the final surgical specimen. ...
The Percentage of [-2]Pro-Prostate-Specific Antigen and the Prostate Health Ind...
Garrido, MM; Marta, JC; Bernardino, RM; Guerra, J; Fernandes, F; Pereira, MH; Ribeiro, R; Holdenrieder, S; Pinheiro, LC; Guimarães, JTContext.— There is a need to avoid the overdiagnosis of prostate cancer (PCa) and to find more specific biomarkers. Objective.— To evaluate the clinical utility of [−2]pro–prostate-specific antigen ([−2]proPSA) derivatives in detecting clinically significant PCa (csPCa) and to compare it with prostate-specific antigen (PSA) and with the percentage of free PSA (%fPSA). Design.— Two hundred thirty-seven men (PSA:...
The Percentage of [−2]Pro–Prostate-Specific Antigen and the Prostate Health Ind...
Garrido, MM; Marta, JC; Bernardino, RM; Guerra, J; Fernandes, F; Pereira, MH; Ribeiro, R; Holdenrieder, S; Pinheiro, LC; Guimarães, JTContext.—: There is a need to avoid the overdiagnosis of prostate cancer (PCa) and to find more specific biomarkers. Objective.—: To evaluate the clinical utility of [-2]pro-prostate-specific antigen ([-2]proPSA) derivatives in detecting clinically significant PCa (csPCa) and to compare it with prostate-specific antigen (PSA) and with the percentage of free PSA (%fPSA). Design.—: Two hundred thirty-seven men (P...
Tumour markers in prostate cancer: The post-prostate-specific antigen era
Garrido, MM; Bernardino, RM; Marta, JC; Holdenrieder, S; Guimarães, JTAlthough prostate-specific antigen-based prostate cancer screening had a positive impact in reducing prostate cancer mortality, it also led to overdiagnosis, overtreatment and a significant number of unnecessary biopsies. In the post-prostate-specific antigen era, new biomarkers have emerged that can complement the information given by prostate-specific antigen, towards a better cancer diagnostic specificity, a...
Extracellular Vesicle Proteome in Prostate Cancer: A Comparative Analysis of Ma...
Bernardino, RM; Leão, R; Henrique, R; Pinheiro, LC; Kumar, P; Suravajhala, P; Beck, HC; Carvalho, AS; Matthiesen, RMolecular diagnostics based on discovery research holds the promise of improving screening methods for prostate cancer (PCa). Furthermore, the congregated information prompts the question whether the urinary extracellular vesicles (uEV) proteome has been thoroughly explored, especially at the proteome level. In fact, most extracellular vesicles (EV) based biomarker studies have mainly targeted plasma or serum. ...