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Plasmonic/magnetic liposomes based on nanoparticles with multicore-shell archit...
Rodrigues, Ana Rita Oliveira; Santos, Lia C. A.; Macedo, Daniela O.; Rio, Irina Soraia Rainho; Pires, Ana; Pereira, André M.; Araújo, João PedroMultifunctional nanosystems are capable to carry one or more therapeutic agents (thermal and/or targeting agents and chemotherapeutic drugs), offering the capability to concurrently perform different treatment modalities using a single nanosystem. Cluster nanostructures, consisting of densely packed aggregates of magnetic nanoparticles, have shown enhanced heating capabilities. Their combination with plasmonic ...
Magnetoliposomes based on magnetic/plasmonic nanoparticles loaded with tricycli...
Rio, Irina Soraia Rainho; Rodrigues, Ana Rita Oliveira; Rodrigues, Juliana M.; Queiroz, Maria João R. P.; Calhelha, R. C.; Ferreira, Isabel C. F. R.Liposome-like nanoarchitectures containing manganese ferrite nanoparticles covered or decorated with gold were developed for application in dual cancer therapy, combining chemotherapy and photothermia. The magnetic/plasmonic nanoparticles were characterized using XRD, UV/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanop...
Synthesis and characterization of magnetoliposomes containing nickel ferrite na...
Rio, Irina Soraia Rainho; Rodrigues, Ana Rita Oliveira; Castanheira, Elisabete M. S.; Coutinho, Paulo J. G.In this work, nanoparticles with magnetic/plasmonic properties of nickel ferrite decorated with gold nanoparticles and core/shell nickel ferrite/gold nanoparticles were prepared and characterized. The synthesized nanoparticles were used for the preparation of solid magnetoliposomes (SMLs), these systems being our target of study. The nanosystems were evaluated for the ability to cause local heating upon excitat...
Magnetic/plasmonic liposomes as nanocarriers for novel antitumor tricyclic lact...
Rodrigues, Ana Rita Oliveira; Rio, Irina Soraia Rainho; Rodrigues, J. M.; Queiroz, Maria João R. P.; Calhelha, Ricardo C.; Ferreira, Isabel C. F. R.In this work, MnFe2O4/Au core/shell nanoparticles (NPs) and MnFe2O4 NPs decorated with Au NPs were synthesized and the structural, spectroscopic and magnetic properties evaluated. The prepared NPs were covered with a lipid bilayer, forming solid magnetoliposomes (SMLs). The heating capabilities of the nanosystems were assessed through the fluorescence quenching of Nile Red (incorporated in the lipid bilayer of ...
Development of NiFe2O4/Au nanoparticles covered with lipid bilayers for applica...
Rodrigues, Ana Rita Oliveira; Rio, Irina Soraia Rainho; Castanheira, Elisabete M. S.; Coutinho, Paulo J. G.The potential of nanosystems with combined magnetic and plasmonic properties for biomedical applications has been recognized. Magnetic nanoparticles can enable magnetic drug targeting and hyperthermia, while plasmonic gold nanoparticles ensure effective local heating (photothermia) using relatively low energies for gold excitation. Considering cancer therapy, the combination of magnetic and plasmonic capabiliti...
Magnetolipossomas multifuncionais contendo nanopartículas magnéticas-plasmónica...
Rio, Irina Soraia RainhoAtualmente, o cancro é uma das principais causas de morte a nível mundial. Apesar das inúmeras investigações e descobertas conseguidas até aos dias de hoje, existem bastantes dificuldades num diagnóstico rápido, bem como em tratamentos direcionados de forma a diminuir os efeitos secundários. Assim, há uma urgência na descoberta de novos métodos de diagnóstico e tratamento. A Nanotecnologia tem, cada vez mais, p...