4 documents found, page 1 of 1
A molecular biophysical approach to diclofenac topical gastrointestinal damage
Fernandes, Eduarda; Soares, Telma B.; Gonçalves, Hugo; Bernstorff, Sigrid; Real Oliveira, M. Elisabete C.D.; Lopes, Carla M.; Lúcio, M.Diclofenac (DCF), the most widely consumed non-steroidal anti-inflammatory drug (NSAID) worldwide, is associated with adverse typical effects, including gastrointestinal (GI) complications. The present study aims to better understand the topical toxicity induced by DCF using membrane models that mimic the physiological, biophysical, and chemical environments of GI mucosa segments. For this purpose, phospholipid...
A molecular biophysical approach to diclofenac topical gastrointestinal damage
Fernandes, Eduarda; Soares, Telma; Gonçalves, Hugo; Bernstorff, Sigrid; Oliveira, Maria Real; Lopes, Carla Martins; Lúcio, MarleneDiclofenac (DCF), the most widely consumed non-steroidal anti-inflammatory drug (NSAID) worldwide, is associated with adverse typical effects, including gastrointestinal (GI) complications. The present study aims to better understand the topical toxicity induced by DCF using membrane models that mimic the physiological, biophysical, and chemical environments of GI mucosa segments. For this purpose, phospholipid...
Influence of RF-sputtering power on formation of vertically stacked Si1−xGex nan...
Vieira, E. M. F.; Martín-Sánchez, J.; Roldan, M. A.; Varela, M.; Buljan, Maja; Bernstorff, Sigrid; Barradas, Nuno P.; Franco, Nuno; Correia, M. R.In this work, we investigate the structural and photoluminescence (PL) properties of (SiGe+Al2O3)/Al2O3 multi-layer films with layer thicknesses in the range of a few nanometres. The films were prepared by magnetron sputtering deposition at room temperature followed by an annealing process to promote the formation of small SiGe nanocrystals (NCs) (∼3 to 5 nm) embedded between ultra-thin (∼6 nm thickness) Al2O3 ...
Structural and electrical studies of ultrathin layers with Si0.7Ge0.3 nanocryst...
Vieira, E. M. F.; Martín-Sánchez, J.; Rolo, Anabela G.; Parisini, Andrea; Buljan, Maja; Capan, I.; Alves, Eduardo; Barradas, Nuno P.; Conde, OlindaIn this work, SiGe/SiO2 multi-layer (ML) films with layer thickness in the range of a few nanometers were successfully fabricated by conventional RF-magnetron sputtering at 350ºC. The influence of the annealing treatment on SiGe nanocrystals (NCs) formation and crystalline properties were investigated by Raman spectroscopy and grazing incidence x-ray diffraction. At the annealing temperature of 800 ºC, where we...