2 documents found, page 1 of 1
Sustained kidney biochemical derangement in treated experimental diabetes : a c...
Oliveira, Antônio Anax Falcão de; Oliveira, Tiago Franco de; Bobadilla, Larissa Letícia; Garcia, Camila Carrião Machado; Berra, Carolina MariaThe occurrence of biochemical alterations that last for a long period of time in diabetic individuals even after adequate handling of glycemia is an intriguing phenomenon named metabolic memory. In this study, we show that a kidney pathway is gradually altered during the course of diabetes and remains persistently changed after late glycemic control in streptozotocin-induced diabetic rats. This pathway comprise...
Plasmid DNA damage induced by singlet molecular oxygen released from the naphth...
Berra, Carolina Maria; Menck, Carlos Frederico Martins; Martinez, Glaucia Regina; Oliveira, Carla Santos de; Baptista, Maurício da SilvaTo investigate oxidative lesions and strand breaks induction by singlet molecular oxygen (1O2), supercoiled-DNA plasmid was treated with thermo-dissociated DHPNO2 and photoactivated-methylene blue. DNA lesions were detected by Fpg that cleaves DNA at certain oxidized bases, and T4-endoV, which cleaves DNA at cyclobutane pyrimidine dimers and apurinic/apyrimidinic (AP) sites. These cleavages form open relaxed-DN...