28 documents found, page 1 of 3

Ezrin protein’s role on cell migration in gastric cancer and identification of ...

Background: Gastric cancer (GC) is the fourth leading cause of cancer-related deaths, often diagnosed in late stages of the disease, limiting treatment options [1-2]. The absence of new therapies and proper diagnosis calls for an exploration of different potential targets. Epitranscriptomics studies RNA chemical modifications such as N6-methyladenosine (m6A), lately studied to understand its effect on cancer pr...

Development of new class of precision antibiotics against multidrug resistant k...

Abstract: The increasing global trend in antimicrobial resistance represents a major public health threat in modern medicine worldwide. Among clinically concerning pathogens are Multidrug resistant (MDR) Klebsiella pneumoniae, classified by the World Health Organization (WHO) as a critical priority pathogen underscoring the urgent need for new antibiotics drugs. In this study we aimed to evaluate the in vitro a...

Antibioterapia em associação com Epigalocatequina-3 galato (EGCG) é uma alterna...

A resistência antimicrobiana de patógenos humanos, como Staphylococcus aureus resistente à meticilina (MRSA), é globalmente definida como uma grande preocupação de saúde pública. Atualmente, várias novas abordagens terapêuticas estão a ser desenvolvidas com o objetivo de encontrar uma alternativa para tratar essas infeções, incluindo o uso de compostos naturais com potencial de modulação epigenética, como as ca...

High-Throughput Drug Screening Revealed That Ciclopirox Olamine Can Engender Ga...

Cancer stem cells (CSCs) are relevant therapeutic targets for cancer treatment. Still, the molecular circuits behind CSC characteristics are not fully understood. The low number of CSCs can sometimes be an obstacle to carrying out assays that explore their properties. Thus, increasing CSC numbers via small molecule-mediated cellular reprogramming appears to be a valid alternative tool. Using the SORE6-GFP repor...

The use of simulation in self-perception of learning in occupational therapy st...

This study aimed to assess the self-perception of students’ learning in Occupational Therapy undergraduate students of School of Health of the Polytechnic of Porto after exposure to a simulated situation of an information collection interview for an occupational profile.

Antibiotherapy in association with Epigallocatechin-3 gallate (EGCG) is an effe...

ABSTRACT - Antimicrobial resistance of human pathogens such as Methicillin-Resistant Staphylococcus aureus (MRSA), is globally defined as a major public health concern. Currently, several new therapeutic approaches are being developed with the aim find an alternative to treat these infections, including the use of natural compounds with epigenetic modulation potential such as green tea catechins. In green tea, ...

Removal of mercury by silica-supported ionic liquids: efficiency and ecotoxicol...

Anthropogenic impacts have affected the coastal environment and contributed to its contamination. Mercury (Hg) is widespread in nature and has been shown to be toxic in even the smallest amounts, negatively affecting not only the marine ecosystem but also the entire trophic chain due to its biomagnification. Mercury ranks third on the Agency for Toxic Substances and Diseases Registry (ATSDR) priority list and i...

Another lesson learned: a commentary on “Montes et al. (2020) neonatal nursing ...

Tradução, adaptação e contributo para a validação da escala Warwick-Edinburgh M...

O conceito de Bem-Estar Mental tem ganho mais destaque internacionalmente, sendo um aspeto crucial da saúde, com impacto na funcionalidade. Assim, em Portugal, impõe-se a necessidade de possuir medidas validadas que avaliem o bem-estar das populações. Traduzir, adaptar culturalmente e contribuir para validar a Warwick-Edinburgh Mental Well-Being Scale (WEMWBS), que avalia o bem-estar mental subjetivo e psicológ...

Efeito modulador da EGCG na transcrição de genes de virulência em Staphylococcu...

Introdução: A resistência de patógenos humanos a múltiplos antibióticos é considerada pela Organização Mundial de Saúde uma ameaça global à saúde humana. Nos últimos anos, vários grupos de investigação têm investido na descoberta de novas moléculas com potencial antimicrobiano para utilização em terapêutica e/ou como adjuvante terapêutico. Um dos microrganismos de interesse, com resistência associada, é o Staph...