5 documents found, page 1 of 1
Malaria determining risk factors at the household level in two rural villages o...
Guerra, Mónica; de Sousa, Bruno; Ndong-Mabale, Nicolas; Berzosa, Pedro; Arez, Ana PaulaBACKGROUND: After the introduction of an artemisinin-based combination therapy, the reduction of prevalence of malaria infections has shown a remarkable progress during the last decade. However due to the lack of a consistent malaria control programme and socioeconomic inequalities, Plasmodium infection is still one of the major cause of disease in Equatorial Guinea, namely in the rural communities. This study ...
Plasmodium falciparum genetic diversity in continental Equatorial Guinea before...
Guerra, Mónica; Neres, Rita; Salgueiro, Patrícia; Mendes, Cristina; Ndong-Mabale, Nicolas; Berzosa, Pedro; de Sousa, Bruno; Arez, Ana PaulaEfforts to control malaria may affect malaria parasite genetic variability and drug resistance, the latter of which is associated with genetic events that promote mechanisms to escape drug action. The worldwide spread of drug resistance has been a major obstacle to controlling Plasmodium falciparum malaria, and thus the study of the origin and spread of associated mutations may provide some insights into the pr...
Genetic diversity and signatures of selection of drug resistance in Plasmodium ...
Mendes, Cristina; Salgueiro, Patrícia; Gonzalez, Vicenta; Berzosa, Pedro; Benito, Agustin; Do Rosário, Virgílio E.; De Sousa, Bruno; Cano, JorgeBackground: In Plasmodium, the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same host may be a source of selection on pathogen virulence and drug resistance. As different patterns have already been described in humans and mosquitoes, parasite diversity and population structure should be studied in both hosts to properly assess their effects on ...
Duffy negative antigen is no longer a barrier to Plasmodium vivax - molecular e...
Mendes, Cristina; Dias, Fernanda; Figueiredo, Joana; Mora, Vicenta Gonzalez; Cano, Jorge; de Sousa, Bruno; do Rosário, Virgílio E.; Benito, AgustinBackground: Plasmodium vivax shows a small prevalence in West and Central Africa due to the high prevalence of Duffy negative people. However, Duffy negative individuals infected with P. vivax have been reported in areas of high prevalence of Duffy positive people who may serve as supply of P. vivax strains able to invade Duffy negative erythrocytes. We investigated the presence of P. vivax in two West African ...
Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulu...
Jambou, Ronan; Martinelli, Axel; Pinto, João; Gribaldo, Simonetta; Legrand, Eric; Niang, Makhtar; Kim, Nimol; Pharath, Lim; Volnay, BéatriceArtemisinin, a thapsigargin-like sesquiterpene has been shown to inhibit the Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase PfSERCA. To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted a sequence analysis of 100 isolates from multiple sites in Africa, Asia and South America. Coding se...