3 documents found, page 1 of 1
Malaria determining risk factors at the household level in two rural villages o...
Guerra, Mónica; Sousa, Bruno de; Ndong-Mabale, Nicolas; Berzosa, Pedro; Arez, Ana PaulaAfter the introduction of an artemisinin-based combination therapy, the reduction of prevalence of malaria infections has shown a remarkable progress during the last decade. However due to the lack of a consistent malaria control programme and socioeconomic inequalities, Plasmodium infection is still one of the major cause of disease in Equatorial Guinea, namely in the rural communities. This study explored the...
Plasmodium falciparum Genetic Diversity in Continental Equatorial Guinea before...
Guerra, Mónica; Neres, Rita; Salgueiro, Patrícia; Mendes, Cristina; Ndong-Mabale, Nicolas; Berzosa, Pedro; Sousa, Bruno de; Arez, Ana PaulaEfforts to control malaria may affect malaria parasite genetic variability and drug resistance, the latter of which is associated with genetic events that promote mechanisms to escape drug action. The worldwide spread of drug resistance has been a major obstacle to controlling Plasmodium falciparum malaria, and thus the study of the origin and spread of associated mutations may provide some insights into the pr...
Genetic diversity and signatures of selection of drug resistance in Plasmodium ...
Mendes, Cristina; Salgueiro, Patrícia; Gonzalez, Vicenta; Berzosa, Pedro; Benito, Agustin; Rosário, Virgílio E. do; Sousa, Bruno de; Cano, JorgeIn Plasmodium, the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same host may be a source of selection on pathogen virulence and drug resistance. As different patterns have already been described in humans and mosquitoes, parasite diversity and population structure should be studied in both hosts to properly assess their effects on infection an...