14 documents found, page 1 of 2
Differential and converging molecular mechanisms of antidepressants' action in ...
Patrício, P.; Pinheiro, António Mateus; Irmler, Martin; Alves, Nuno D.; Santos, Ana R. Machado; Morais, Mónica; Silva-Correia, JoanaMajor depression is a highly prevalent, multidimensional disorder. Although several classes of antidepressants (ADs) are currently available, treatment efficacy is limited, and relapse rates are high; thus, there is a need to find better therapeutic strategies. Neuroplastic changes in brain regions such as the hippocampal dentate gyrus (DG) accompany depression and its amelioration with ADs. In this study, the ...
The effects of chronic stress on hippocampal adult neurogenesis and dendritic p...
Bessa, J. M.; Pinto, Luisa; Morais, Mónica; Sousa, Nuno; Patrício, P.; Pinheiro, António Mateus; Almeida, Susana; Filipe, Augusto; Pedroso, PedroOnline first version - Oct 14, 2014; There is accumulating evidence that adult neurogenesis and dendritic plasticity in the hippocampus are neuroplastic phenomena, highly sensitive to the effects of chronic stress and treatment with most classes of antidepressant drugs, being involved in the onset and recovery from depression. However, the effects of antidepressants that act through the selective inhibition of ...
The sweet drive test : refining phenotypic characterization of anhedonic behavi...
Pinheiro, António Mateus; Patrício, P.; Alves, N. D.; Santos, Ana R. Machado; Morais, Mónica; Bessa, J. M.; Sousa, Nuno; Pinto, LuisaMeasuring anhedonic behavior in rodents is a challenging task as current methods display only moderate sensitivity to detect anhedonic phenotype and, consequently, results from different labs are frequently incongruent. Herein we present a newly-developed test, the Sweet Drive Test (SDT), which integrates food preference measurement in a non-aversive environment, with ultrasonic vocalizations (USVs) recording. ...
Cell genesis and dendritic plasticity: a neuroplastic pas de deux in the onset ...
Pinheiro, António Mateus; Patrício, P.; Bessa, J. M.; Sousa, Nuno; Pinto, LuísaBrain neuroplasticity is increasingly considered to be an important component of both the pathology and treatment of depressive spectrum disorders. Recent studies shed light on the relevance of hippocampal cell genesis and cortico-limbic dendritic plasticity for the development and remission from depressive-like behavior. However, the neurobiological significance of neuroplastic phenomena in this context is sti...
Sustained remission from depressive-like behavior depends on hippocampal neurog...
Pinheiro, António Mateus; Pinto, Luísa; Bessa, J. M.; Morais, Mónica; Alves, N. D.; Monteiro, S.; Patrício, P.; Almeida, O. F. X.; Sousa, NunoImpairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms...
Perceived stress in obsessive-compulsive disorder is related with obsessive but...
Morgado, Pedro; Freitas, D.; Bessa, J. M.; Sousa, Nuno; Cerqueira, JoãoObsessive–compulsive disorder (OCD) is achronic psychiatric disorder characterized by recurrent intrusive thoughts and/or repetitive compulsory behaviors. This psychiatric disorder is known to be stress responsive, as symptoms increase during periods of stress but also because stressful events may precede the onset of OCD. However, only a few and inconsistent reports have been published about the stress percept...
Immuno-Golgi as a tool for analyzing neuronal 3D-dendritic structure in phenoty...
Pinto, Luísa; Pinheiro, António Mateus; Morais, Mónica; Bessa, J. M.; Sousa, NunoCharacterization of neuronal dendritic structure in combination with the determination of specific neuronal phenotype or temporal generation is a challenging task. Here we present a novel method that combines bromodioxyuridine (BrdU) immunohistochemistry with Golgi-impregnation technique; with this simple noninvasive method, we are able to determine the tridimensional structure of dendritic arborization and spi...
A trans-dimensional approach to the behavioral aspects of depression
Bessa, J. M.; Mesquita, Ana Raquel Marcelino; Oliveira, Mário; Pêgo, José M.; Cerqueira, João José; Palha, Joana Almeida; Almeida, O. F. X.; Sousa, NunoDepression, a complex mood disorder, displays high comorbidity with anxiety and cognitive disorders. To establish the extent of inter-dependence between these behavioral domains, we here undertook a systematic analysis to establish interactions between mood [assessed with the forced-swimming (FST) and sucrose consumption tests (SCT)], anxiety [elevated-plus maze (EPM) and novelty suppressed feeding (NSF) tests]...
The mood-improving actions of antidepressants do not depend on neurogenesis but...
Bessa, J. M.; Ferreira, D.; Melo, I.; Marques, F.; Cerqueira, João José; Palha, Joana Almeida; Almeida, O. F. X.; Sousa, NunoThe mechanisms underlying the initiation/onset of, and the recovery from, depression are still largely unknown; views that neurogenesis in the hippocampus may be important for the pathogenesis and amelioration of depressive symptoms have gained currency over the years although the original evidence has been challenged. In this study, an unpredictable chronic mild stress protocol was used to induce a depressive-...
Hippocampal neurogenesis induced by antidepressant drugs: an epiphenomenon in t...
Bessa, J. M.; Ferreira, D.; Melo, I.; Marques, F.; Cerqueira, João José; Palha, Joana Almeida; Almeida, O. F. X.; Sousa, NunoImage of a niche of newly formed neurons in the subgranular zone of the hippocampal dentate gyrus, obtained by confocal microscopy. Red: Ki-67-positive cells; green: DCX-positive cells; GCL: granule cell layer; SGZ: subgranular zone. For more information on this topic, please refer to the article by Bessa et al. on pages 764–773.; (undefined)