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Synthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides

Brango-Vanegas, J; Martinho, L; Bessa, L; Vasconcelos, A; Plácido, A; Pereira, A; Leite, J; Machado, A

Eight new sulfide-based cyclic peptidomimetic analogues of solonamides A and B have been synthesized via solid-phase peptide synthesis and SN2’ reaction on a Morita–Baylis–Hillman (MBH) residue introduced at the N-terminal of a tetrapeptide. This last step takes advantage of the electrophilic feature of the MBH residue and represents a new cyclization strategy occurring. The analogues were prepared in moderate ...

Date: 2019 | Origin: Repositório Aberto da Universidade do Porto

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