6 documents found, page 1 of 1
Peptide conjugates for the topical treatment of infected wounds
Gomes, Ana; Fernandes, Iva; Bessa, Lucinda; Ferreira, Mariana; Maciel, Joana; Plácido, Alexandra; Teixeira, Cátia; Leal, Ermelindo; Ferraz, RicardoDue to widespread multidrug-resistant (MDR) microbes, efficient treatments for infected wounds are being exhausted.1 The symptoms of wound infection are consistent with local polymicrobial biofilms, which are difficult to eliminate and delay the healing process. The current standard of care requires oral antibiotics and other measures, often complex and distressing (e.g., amputations). A perfect treatment shoul...
Peptide-ionic liquid conjugates towards the treatment of skin infections
Gomes, Ana; Bessa, Lucinda; Fernandes, Iva; Teixeira, Cátia; Aguiar, Luísa; Ferraz, Ricardo; Monteiro, Cláudia; Martins, Cristina; Mateus, NunoThe treatment of complicated skin infections, like diabetic foot ulcers and other chronic wounds, are often associated with persistent polymicrobial biofilms that delay and difficult the healing process. The most severe cases culminate in inpatient hospital admission, where infections can be exacerbated by hospital-acquired pathogens, in particular, if caused by the so-called ESKAPE pathogens, for which few eff...
Peptide/ionic liquid conjugates to tackle complicated skin infections: antimicr...
Gomes, Ana; Bessa, Lucinda; Fernandes, Iva; Aguiar, Luisa; Ferraz, Ricardo; Monteiro, Cláudia; Martins, Cristina; Mateus, Nuno; Gameiro, PaulaComplicated skin and soft tissue infections (cSSTI) like, e.g., diabeticfoot ulcers (DFU), are severe cases of cutaneous and deeper soft tis-sue infections. Their symptoms are consistent with local polymicro-bial biofilms, which are difficult to eliminate and delay the healing process. The standard-of-care for cSSTI requires oral antibiotics andother measures, often complex and distressing (e.g., amputations). ...
Antimicrobial and antibiofilm activity of unionid mussels from the north of Por...
Hinzmann, Mariana; Bessa, Lucinda; Teixeira, Amílcar; Costa, Paulo M. da; Machado, JorgeThe populations of freshwater mussels belonging to the family Unionidae have been facing drastic changes in terms of diversity and numbers caused by constant aggressions on their natural habitat. Nevertheless, bivalves are capable of developing strategies of defense to overcome potential aggressors. The present work aimed to assess the potential antibacterial capacity of different species of unionid mussels fro...
Dual-action peptides as potential novel topical agents for treatment of skin an...
Gomes, Ana; Bessa, Lucinda; Ferraz, Ricardo; Prudêncio, Cristina; Gameiro, Paula; Teixeira, Cátia; Gomes, PaulaChronic skin and soft-tissue infections (SSTI) such as diabetic foot ulcers (DFU) exhibit signs and symptoms that are consistent with localized bacterial biofilms that contribute to tissue destruction, delayed woundhealing and other serious complications. As such, most current approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often co...
Chemical Composition, Antibacterial, Antibiofilm and Synergistic Properties of ...
Vieira, Maria; Bessa, Lucinda; Martins, M. Rosario; Arantes, Silvia; Teixeira, António; Mendes, Angelo; Martins da Costa, Paulo; Belo, A.D.F.Essential oils (EOs) from Eucalyptus globulus LABILL. ssp. globulus and from Mediterranean autochthonous aromatic plants – Thymus mastichina L., Mentha pulegium L., Rosmarinus officinalis L., Calamintha nepeta (L.) SAVI ssp. nepeta, Cistus ladanifer L., Foeniculum vulgare L., Dittrichia viscosa (L.) GREUTER ssp. viscosa – were extracted by hydrodistillation and characterized by GC-FID and NMR spectroscopy. EOs ...