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NT-proBNP no diagnóstico de insuficiência cardíaca nos cuidados de saúde primários

Fonseca, Cândida; Bettencourt, Paulo; Brito, Dulce; Febra, Helena; Pereira, Álvaro; Genovez, Victória; Lopes, Nelson

Funding Information: This study was supported by Roche Diagnostics. The authors had full control of the content and made the final decision on all aspects of this article. Publisher Copyright: © 2021 Sociedade Portuguesa de Cardiologia; Introduction and objectives: Chronic heart failure (CHF) is a growing public health concern and diagnosis can be challenging, particularly in primary care. This study aims to es...


Management of RAASi-associated hyperkalemia in patients with cardiovascular dis...

Silva-Cardoso, José; Brito, Dulce; Frazão, João Miguel; Ferreira, Aníbal; Bettencourt, Paulo; Branco, Patrícia; Fonseca, Cândida

Renin–angiotensin–aldosterone system inhibitors (RAASi) reduce morbidity and mortality in heart failure (HF) with reduced ejection fraction in a dose-dependent manner. They also have a positive impact in other cardiovascular diseases (CVDs). However, RAASi may induce hyperkalemia, a potentially life-threatening disorder. This risk is further increased in those with concomitant chronic kidney disease, diabetes m...


Hipercaliemia e otimização dos inibidores do sistema renina-angiotensina-aldost...

Fonseca, Cândida; Brito, Dulce; Branco, Patrícia; Frazão, João Miguel; Silva-Cardoso, José; Bettencourt, Paulo

Introduction and Objectives: Renin-angiotensin-aldosterone system inhibitors (RAASi) are the cornerstone of treatment of heart failure with reduced ejection fraction (HFrEF). RAASi optimization in real-life care is challenged by hyperkalemia, a potentially fatal adverse event, which can necessitate downtitration or discontinuation of RAASi and negatively impact survival in HFrEF. The literature on this problem ...


Interpretação dos peptídeos natriuréticos tipo B na era dos antagonistas da nep...

Bettencourt, Paulo; Fonseca, Cândida; Franco, Fátima; Andrade, Aurora; Brito, Dulce

Copyright © 2017 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.; Assessment of serum levels of natriuretic peptides, especially the amino-terminal portion (NT-proBNP) and the carboxy-terminal portion (BNP) of pro-B-type natriuretic peptide, has had a highly significant clinical impact on the diagnosis and prognostic stratification of patients with heart failure (...


A closer look at acute heart failure

Fonseca, Cândida; Araújo, Inês; Marques, Filipa; Brás, Daniel; Bettencourt, Paulo

Publisher Copyright: © 2016 Sociedade Portuguesa de Cardiologia.; Introduction and Objectives Acute heart failure (AHF) is a heterogeneous clinical syndrome requiring urgent therapy. The prognosis is poor after the index hospitalization, with a high risk for rehospitalization and early death. The costs of managing AHF are thus increasing rapidly. A literature review was performed to gather and compare data on p...


Dabigatran for stroke prevention in nonvalvular atrial fibrillation

Ferreira, Jorge; Ferreira, Daniel; Viana-Baptista, Miguel; Bettencourt, Paulo; Cernadas, Rui; Crespo, Francisco

Dabigatran etexilate is a novel, oral, reversible, direct thrombin inhibitor that constitutes a major breakthrough for stroke prevention in patients with nonvalvular atrial fibrillation (AF). Dabigatran was the first new oral anticoagulant approved in Europe and became available in Portugal, for stroke prevention in nonvalvular AF, earlier than in most European countries. This paper is the joint effort of a pan...


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