27 documents found, page 1 of 3

A first-takes-all model of centriole copy number control based on cartwheel elo...

From centrosomal microtubule anchoring and organization to basal body positioni...

Cilia are microtubule-based organelles that protrude from the cell surface and fulfill critical motility and sensory functions being required for normal embryonic development and for homeostasis of human adult tissues. Cilia loss or dysfunction is associated with human ciliopathies. At their base cilia have a centriole/basal body (BB), which can be derived from the centrosome and assembles the ciliary axoneme. ...

TBCCD1: a new player in the development of ciliopathies?

Project IPL/2016/TBCCentro_ESTeSL.; Project IPL/2017/CILIOPAT/ESTeSL; Cilia are hair-like appendages, consisting of a microtubule (MT)-based ciliary axoneme, which fulfill critical motility and sensory functions required for normal embryonic development and also for homeostasis of adult tissues. At their base, cilia have a centriole/basal body, which can be derived from the centrosome, and that nucleates the ci...

Centrosome positioning and development of ciliopathies: role of the human centr...

Project IPL/2019/MOONOFCILI/ESTeSL; Aims/Context: Primary cilia are specialized microtubule-based signaling organelles that convey extracellular signaling and cellular polarity into a cellular response. Defects in primary cilia assembly/function cause severe diseases known as ciliopathies, typified by clinical manifestations, like infertility, obesity, brain problems, blindness, and kidney cysts. Primary cilia ...

Pan-cancer association of a centrosome amplification gene expression signature ...

Copyright: © 2019 de Almeida et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.; Centrosome amplification (CA) is a common feature of human tumours and a promising target for cancer therapy. However, CA's pan-cancer preval...

Pericentrin-mediated SAS-6 recruitment promotes centriole assembly

The centrosome is composed of two centrioles surrounded by a microtubule-nucleating pericentriolar material (PCM). Although centrioles are known to regulate PCM assembly, it is less known whether and how the PCM contributes to centriole assembly. Here we investigate the interaction between centriole components and the PCM by taking advantage of fission yeast, which has a centriole-free, PCM-containing centrosom...

Differential regulation of transition zone and centriole proteins contributes t...

Cilia are evolutionarily conserved structures with many sensory and motility-related functions. The ciliary base, composed of the basal body and the transition zone, is critical for cilia assembly and function, but its contribution to cilia diversity remains unknown. Hence, we generated a high-resolution structural and biochemical atlas of the ciliary base of four functionally distinct neuronal and sperm cilia ...

Over-elongation of centrioles in cancer promotes centriole amplification and ch...

This deposit is composed by the main article plus the supplementary materials of the publication.; Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell ...

Centrosome amplification arises before neoplasia and increases upon p53 loss in...

The uploaded article version is the Epub Ahead of Print version of the article, posted online 8 May 2018. It has been submitted to peer-review.; The deposited article version contains attached the supplementary materials within the pdf.; Centrosome abnormalities are a typical hallmark of human cancers. However, the origin and dynamics of such abnormalities in human cancer are not known. In this study, we examin...

Noncanonical Biogenesis of Centrioles and Basal Bodies

The deposited article is a pre-print version.; The deposited article version is the Epub Ahead of Print version of the article, posted online 23 April 2018, provided by Cold Spring Harbor Laboratory Press. It hasn't peer-review.; This deposit is composed by the main article, and it hasn't any supplementary materials associated.; Centrioles and basal bodies (CBBs) organize centrosomes and cilia within eukaryotic...