2 documents found, page 1 of 1
The cholesterol 24-hydroxylase activates autophagy and decreases mutant hunting...
Nóbrega, Clévio; Conceição, André Francisco da; Costa, Rafael G; Koppenol, Rebekah; Sequeira, Raquel L; Nunes, Ricardo; Carmo-Silva, SaraObjective: Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD). Following our previous studies in HD, in this study we aim to investigate in vitro in a neuroblastoma cellular model of HD, the effect of CYP46A1 overexpression, an essential enzyme in cholesterol metabolism, on hunti...
The cholesterol 24-hydroxylase activates autophagy and decreases mutant hunting...
Nóbrega, Clévio; Conceição, André; Costa, Rafael G; Koppenol, Rebekah; Sequeira, Raquel L.; Nunes, Ricardo; Carmo-Silva, Sara; Marcelo, AdrianaObjective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD). Following our previous studies in HD, in this study we aim to investigate in vitro in a neuroblastoma cellular model of HD, the effect of CYP46A1 overexpression, an essential enzyme in cholesterol metabolism, on huntin...