7 documents found, page 1 of 1

Unveiling the genome of Limtongozyma cylindracea

tRNAs as a driving force of genome evolution in yeast

Transfer RNAs (tRNAs) are widely known for their roles in the decoding of the linear mRNA information into amino acid sequences of proteins. They are also multifunctional platforms in the translation process and have other roles beyond translation, including sensing amino acid abundance, interacting with the general stress response machinery, and modulating cellular adaptation, survival, and death. In this mini...

The role of non-standard translation in Candida albicans pathogenesis

Candida albicans typically resides in the human gastrointestinal tract and mucosal membranes as a commensal organism. To adapt and cope with the host immune system, it has evolved a variety of mechanisms of adaptation such as stress-induced mutagenesis and epigenetic regulation. Niche-specific patterns of gene expression also allow the fungus to fine-tune its response to specific microenvironments in the host a...

The impact of a codon reassignment event on the evolution of the yeast C.cylind...

The genetic code is degenerate allowing for introduction of species specific codon utilization biases. These has been intensively studied but it is not yet clear whether they arise from mutational pressure alone or whether other forces, such as the translational efficiency, also influence it To address this question we took advantage of a unique genetic code alteration that occurred in the fungal Saccharomycoti...

The genome of Candida cylindracea to study the role of the translational machin...

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Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel developmen...

Background - MicroRNAs (miRNAs) are a class of small RNAs that are implicated in the control of eukaryotic gene expression by binding to the 3′UTR of target mRNAs. Several algorithms have been developed for miRNA target prediction however, experimental validation is still essential for the correct identification of miRNA targets. We have recently predicted that Neuropilin2a (Nrp2a), a vascular endothelial growt...

Ethanol exposure induces upregulation of specific microRNAs in zebrafish embryos

Prenatal exposure to ethanol leads to a myriad of developmental disorders known as fetal alcohol spectrum disorder, often characterized by growth and mental retardation, central nervous system damage, and specific craniofacial dysmorphic features. The mechanisms of ethanol toxicity are not fully understood, but exposure during development affects the expression of several genes involved in cell cycle control, a...