2 documents found, page 1 of 1
Tropane alkaloids from the stem bark of Erythroxylum bezerrae
Brito, Luana San de O.; Pinto, Francisco das Chagas L.; Moraes Filho, Manoel Odorico de; Rocha, Danilo D.; Mendoza, Maria Fernanda M.Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, P...
Engenharia de cristais aplicada nos fármacos nitroimidazólicos: secnidazol e be...
Bezerra, Beatriz PinheiroSecnidazole and benznidazole drugs are key nitroimidazoles for the treatment of diseases affecting economically disadvantaged populations. In this work we address two problems, the first of the secnidazol, a widely used drug, lacking studies on the possible phase transformations that is possible, since it is a hydrate, in which form it is marketed.The second target of study is benznidazole, the drug of choice f...