9 documents found, page 1 of 1
Biological and physical approaches on the role of piplartine (piperlongumine) i...
Henrique, Tiago; Zanon, Caroline de F. [UNESP]; Girol, Ana P. [UNESP]; Stefanini, Ana Carolina Buzzo; Contessoto, Nayara S. de A. [UNESP]Made available in DSpace on 2021-06-25T10:47:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Chronic inflammation provides a favorable microenvironment for tumorigenesis, which opens opportunities for targeting cancer development and progression. Piplartine (PL) i...
Experimental and theoretical study on spectral features, reactivity, solvation,...
Costa, Renyer A.; Barros, Gabriel de A.; da Silva, Jonathas N. [UNESP]; Oliveira, Kelson M.; Bezerra, Daniel P.; Soares, Milena B.P.; Costa, Emmanoel V.Made available in DSpace on 2021-06-25T10:19:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-05; In this study, guadiscine (G1) and guadiscidine (G2), 7,7-dimethylaporphine alkaloids from Guatteria friesiana, have they geometric paramaters, vibrational behavior and quantum chemical properties (HOMO-LUMO, MEP, ALIE and Fukui indices) analyzed through a theoretical view, by density functional theory ...
Docking, synthesis and antiproliferative activity of N-acylhydrazone derivative...
Amaral, Daniel Nascimento do; Cavalcanti, Bruno C.; Bezerra, Daniel P.; Ferreira, Paulo Michel P.; Castro, Rosane de Paula; Sabino, José RicardoCancer is the second most common cause of death in the USA. Among the known classes of anticancer agents, the microtubule-targeted antimitotic drugs are considered to be one of the most important. They are usually classified into microtubule-destabilizing (e.g., Vinca alkaloids) and microtubule-stabilizing (e.g., paclitaxel) agents. Combretastatin A4 (CA- 4), which is a natural stilbene isolated from Combretum ...
Inhibition of DNA topoisomerase I activity and induction of apoptosis by thiaza...
Barros, Francisco W.A.; Bezerra, Daniel P.; Ferreira, Paulo M. P.; Cavalcanti, Bruno C.; Silva, Teresinha G.; Pitta, Marina G. R.Thiazacridine derivatives (ATZD) are a novel class of cytotoxic agents that combine an acridine and thiazolidine nucleus. In this study, the cytotoxic action of four ATZD were tested in human colon carcinoma HCT-8 cells: (5Z)-5-acridin-9-ylmethylene-3-(4-methylbenzyl)-thiazolidine-2,4-dione — AC-4; (5ZE)-5-acridin-9- ylmethylene-3-(4-bromo-benzyl)-thiazolidine-2,4-dione — AC-7; (5Z)-5-(acridin-9-ylmethylene)-3-...
(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerizat...
Magalhães, Hemerson I. F.; Wilke, Diego V.; Bezerra, Daniel P.; Cavalcanti, Bruno C.; Rotta, Rodrigo; Lima, Dênis P. de; Beatriz, Adilson(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone (PHT) is a known cytotoxic compound belonging to the phenstatin family. However, the exact mechanism of action of PHT-induced cell death remains to be determined. The aim of this study was to investigate the mechanisms underlying PHT-induced cytotoxicity. We found that PHT displayed potent cytotoxicity in different tumor cell lines, showing IC50 values in the n...
Cytotoxic effect of leaf essential oil of Lippia gracilis Schauer (Verbenaceae)
Ferraz, Rosana P.C.; Bomfim, Diogo S.; Carvalho, Nanashara C.; Soares, Milena B.P.; Silva, Thanany B. da; Machado, Wedna J.; Prata, Ana Paula N.Medicinal plants are one of the most important sources of drugs used in the pharmaceutical industry. Among traditional medicinal plants, Lippia gracilis Schauer (Verbenaceae) had been used for several medicinal purposes in Brazilian northeastern. In this study, leaf essential oil (EO) of L. gracilis was prepared using hydrodistillation. Followed by GC–MS analysis, its composition was characterized by the presen...
Antitumour properties of the leaf essential oil of Xylopia frutescens Aubl. (An...
Ferraz, Rosana P.C. Ferraz; Cardoso, Gabriella M.B.; Silva, Thanany B. da; Fontes, José Eraldo do N.; Prata, Ana Paula do N.; Carvalho, Adriana A.The aim of this study was to investigate the chemical composition and anticancer effect of the leaf essen- tial oil of Xylopia frutescens in experimental models. The chemical composition of the essential oil was analysed by GC/FID and GC/MS. In vitro cytotoxic activity of the essential oil was determined on cultured tumour cells. In vivo antitumour activity was assessed in Sarcoma 180-bearing mice. The major co...
Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annon...
Fontes, José Eraldo do N.; Ferraz, Rosana P. C.; Britto, Anny C. S.; Carvalho, Adriana A.; Moraes Filho, Manoel Odorico de; Pessoa, ClaudiaGuatteria pogonopus Martius , a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumo...
Antitumor effect of laticifer proteins of Himatanthus drasticus (Mart.) Plumel ...
Mousinho, Kristiana C.; Oliveira, Cecília de C.; Ferreira, José Roberto de O.; Carvalho, Adriana A.; Magalhães, Hemerson Iury F.; Bezerra, Daniel P.Ethnopharmacological relevance: Himatanthus drasticus (Mart.) Plumel – Apocynaceae is a medicinal plant popularly known as Janaguba. Its bark and latex have been used by the public for cancer treatment, among other medicinal uses. However, there is almost no scientific research report on its medicinal properties. Aim of the study: The aim of this study was to investigate the antitumor effects of Himatanthus dra...