13 documents found, page 1 of 2
Ru(II)-thymine complex causes DNA damage and apoptotic cell death in human colo...
Silva, Suellen Laila Rocha; Baliza, Ingrid R. S.; Dias, Rosane Borges; Sales, Caroline Brandi Schlaepfer; Rocha, Clarissa Araújo GurgelRu(II)-thymine complex [Ru(PPh3)2(Thy)(bipy)]PF6 (where PPh3 = triphenylphosphine, Thy = thyminate and bipy = 2,2′-bipyridine) is a potent cytotoxic agent with ability to bind to DNA, inducing caspase-mediated apoptosis in leukemia cells. In this study, we investigated the mechanism underlying the cell death induction by Ru(II)-thymine complex in human colon carcinoma HCT116 cells, as well as its effect in xeno...
Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell prol...
Bomfim, Larissa Mendes; Araujo, Fênix Alexandra de; Dias, Rosane Borges; Sales, Caroline Brandi Schlaepfer; Rocha, Clarissa Araújo GurgelRuthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2) (where PPh3 = triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellular underlying mechanism and in vivo effectiveness of these ruthenium(II) complexes in human acu...
Nucleobase derivatives as building blocks to borm Ru(II)-based complexes with h...
Carvalho, Diogo Émerson Leite de; Oliveira, Katia Mara de; Bomfim, Larissa Mendes; Soares, Milena Botelho Pereira; Bezerra, Daniel PereiraTwo new Ru(II)-based complexes containing 2-thiouracil derivatives, known as 2-thiouracil (2TU) and 6-methyl-2-thiouracil (6m2TU), were synthesized using cis,trans-[RuCl2(PPh3)2(bipy)] as a precursor. The obtained compounds with a general formula trans-[Ru(2TU)(PPh3)2(bipy)]PF6 (1) and trans-[Ru(6m2TU)(PPh3)2(bipy)]PF6 (2) were characterized by analytical techniques such as NMR, UV–vis, and IR spectroscopies, e...
An investigation into the interaction between piplartine (piperlongumine)and hu...
de Alcântara-Contessoto, Nayara Sousa [UNESP]; Caruso, Ícaro Putinhon [UNESP]; Bezerra, Daniel Pereira; Filho, José Maria BarbosaMade available in DSpace on 2019-10-06T16:31:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-09-05; Piplartines are alkaloid amides present in the roots and stems of different pepper species which have promising pharmacological properties including cancer prevention. Some recent studies have determined pharmacokinetic parameters of piplartine in rat blood plasma but without pointing to any molecular t...
Ru(II)-thymine complex causes cell growth inhibition and induction of caspase-m...
Oliveira, Maiara de Souza; Santana, Adila Angélica Dantas de; Correa, Rodrigo de Souza; Soares, Milena Botelho Pereira; Batista, Alzir AzevedoRuthenium-based compounds represent a class of potential antineoplastic drugs. Recently, we designed, synthesized, and identified the Ru(II)-thymine complex [Ru(PPh3)2(Thy)(bipy)]PF6 (where PPh = triphenylphosphine, Thy = thymine and bipy = 2,2′-bipyridine) as a potent cytotoxic agent with the ability to bind to DNA and human and bovine serum albumins. In this study, the underlying cytotoxic mechanism of the [R...
A novel platinum complex containing a piplartine derivative exhibits enhanced c...
Oliveira, Maiara de Souza; Barbosa, Marília Imaculada Frazão; Souza, Thiago Belarmino de; Moreira, Diogo Rodrigo de Magalhães; Martins, Felipe TerraPiplartine (piperlongumine) is a plant-derived compound found in some Piper species that became a novel potential antineoplastic agent. In the present study, we synthesized a novel platinum complex containing a piplartine derivative cis-[PtCl(PIP-OH)(PPh3)2]PF6 (where, PIP-OH = piplartine demethylated derivative; and PPh3 = triphenylphosphine) with enhanced cytotoxicity in different cancer cells, and investigat...
Anti-liver cancer activity in vitro and in vivo induced by 2-pyridyl 2,3-thiazo...
Silva, Thiago David dos Santos; Bomfim, Larissa Mendes; Rodrigues, Ana Carolina Borges da Cruz; Dias, Rosane Borges; Sales, Caroline Brandi SchlaepferSubmitted by Renorbio (renorbioba@ufba.br) on 2018-05-02T18:48:24Z No. of bitstreams: 1 ANTI-LIVER CANCER ACTIVITY IN VITRO AND IN VIVO INDUCED BY 2-PYRIDYL 2,3-THIAZOLE DERIVATIVES.pdf: 2793458 bytes, checksum: fcbb9a4336522af9d68dd7cdd4ded487 (MD5); Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2018-05-04T14:23:31Z (GMT) No. of bitstreams: 1 ANTI-LIVER CANCER ACTIVITY IN VITRO AND IN VIVO I...
Preclinical anticancer effectiveness of a fraction from Casearia sylvestris and...
Pinheiro Ferreira, Paulo Michel; Bezerra, Daniel Pereira; Silva, Jurandy do Nascimento; Costa, Marcilia Pinheiro da; Oliveira Ferreira, Jose Roberto deMade available in DSpace on 2018-11-27T16:55:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-06-20; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Ethnopharmacological relevance: Casearia sylvestris (Salicaceae) is found in South America and presents antiulcerogenic, cytotoxic, antimicrobial, anti-inflammatory and antihypertensive activities. Aim of the study: To assess the in v...
A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptos...
Silva, Valdenizia Rodrigues; Correa, Rodrigo de Souza; Santos, Luciano de Souza; Soares, Milena Botelho Pereira; Batista, Alzir AzevedoCombination of multifunctionalities into one compound is a rational strategy in medicinal chemical design, and have often been used with metallodrug-based compounds. In the present study, we synthesized a novel ruthenium-based 5-fluorouracil complex [Ru(5-FU)(PPh3)2(bipy)]PF6 (PPh3 = triphenylphosphine; and bipy = 2,2′-bipyridine) with enhanced cytotoxicity in different cancer cells, and assessed its apoptosis ...
Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in...
Pereira, Denyson Santana; Morais, Janaína Pereira; Santana, Danielle Gomes; Santos, Cliomar Alves; Thomazzi, Sara Maria; Santos, Charles Estevam dosIn this study, the ethanol extract of the inner bark of the Syderoxylum obtusifolium (EESob) was tested in the model of cyclophosphamide-induced hemorrhagic cystitis. Male Wistar rats were submitted to the injection of cyclophosphamide, 1 h after the treatment with EESob (200 or 400 mg/kg) or vehicle. After 24 h, the urinary bladder was excised and the edema, myeloperoxidase activity and malondialdehyde formati...