2 documents found, page 1 of 1
Toxicology and safety of the tincture of Operculina alata in patients with func...
Santos, Luciana Kelly Ximenes dos; Cunha, Gilmara Holanda da; Fechine, Francisco Vagnaldo; Pontes, Andréa Vieira; Oliveira, Jonaina Costa deThe tincture of Operculina alata, popularly known as "tincture of jalapa", is used in Northeast Brazil to treat constipation and encephalic vascular accident, but it has not yet been adequately tested for safety and efficacy. The aim of this study was to evaluate the toxicology and safety of the tincture of O. alata in patients with functional constipation. This was a double-blind, randomized, placebo-controlle...
Estudo fase I do cloridrato do (1R, 2R)-(+)-N-metil-N-[2 (1-pirrolidinil) ciclo...
Bezerra, Fernando Antonio FrotaOrientador: Gilberto de Nucci; Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas; Resumo: O presente trabalho,um ensaio clínico Fase I, aberto, com doses únicas crescentes. teve como propósitos avaliar, em voluntários humanos sadios, a tolerância, a segurança, possíveis efeitos farmacodinâmicos e o perfil farmacocinético do Cloridrato de (1R,2R) -(+)¬N-metil- N- [2-(1-pir...