A esquistossomose é uma doença endêmica causada pelo parasito Schistosoma mansoni, cuja infecção ocorre através do contato com a água contaminada. A prevalência se dá em áreas tropicais e subtropicais, em comunidades carentes sem acesso a água potável e saneamento básico, sendo a maioria comunidades pobres e rurais. Nosso projeto vem sendo realizado nas cidades do estado do Ceará: Capistrano e Jaguaretama, na q...
As ações de controle e vigilância da esquistossomose dos Programas de Controle da Esquistossomose (PCE) têm grande relevância, em especial em contextos de grandes intervenções ambientais como o Projeto de Integração do Rio São Francisco (PISF), que afetará a dinâmica de transmissão. O objetivo desse estudo foi avaliar o desenvolvimento das ações do PCE em municípios da região Sul do Estado do Ceará que serão di...
The wide eco-bio-social intervention generated by the SaoFrancisco River Integration Project (PISF) may contribute to the dispersion or introduction of schistosomiasis intermediate hosts in areas without prior recording. The objective was to characterize the limnic malacofauna and its distribution along watersheds involved in the PISF. A cross-sectional study based on the collection of mollusks from 33 water bo...
INTRODUCTION: The development of the São Francisco River Integration Project [Projeto de Integração do Rio São Francisco (PISF)] in the State of Ceará, Brazil, has resulted in environmental and socioeconomic changes with potential risks to public health. We aimed to determine the presence of Schistosoma mansoni infections in schoolchildren (aged 7-14 years) and workers from the construction site in an area unde...
Abstract: Background: Treatment with benzonidazole in the chronic phase of Chagas disease remains controversial. This study is aimed at evaluating the effectiveness of chemotherapy with benzonidazole in chronic Chagas disease using serological and electrocardiographic analysis. Method: Historical prospective study with electrocardiographic and serological monitoring by enzyme immunoassay (ELISA) and indirect im...
We analyzed spatiotemporal patterns of 8,756 schistosomiasis- related deaths in Brazil during 2000–2011 and identified high-risk clusters of deaths, mainly in highly schistosomiasis- endemic areas along the coast of Brazil’s Northeast Region. Schistosomiasis remains a neglected public health problem with a high number of deaths in disease-endemic and emerging focal areas.
Aiming at demonstrating a decrease of acquired immunity after chemotherapeutic cure, a group of mice was infected with 25 Schistosoma mansoni cercariae (LE strain). A part of these animals was treated with 400 mg/kg oxamniquine, at 120 days after infection. Challenge infections were carried out at 45, 90 and 170-day-intervals after treatment (185, 210 and 290 days after primoinfection, respectively). Recovery o...