2 documents found, page 1 of 1
In vitro and in vivo effects of SerpinA1 on the modulation of Transthyretin pro...
Bezerra, Filipa; Niemietz, Christoph; Schmidt, Hartmut H. J.; Zibert, Andree; Guo, Shuling; Monia, Brett P.; Gonçalves, Paula Isabel MeiraTransthyretin (TTR) proteolysis has been recognized as a complementary mechanism contributing to transthyretin-related amyloidosis (ATTR amyloidosis). Accordingly, amyloid deposits can be composed mainly of full-length TTR or contain a mixture of both cleaved and full-length TTR, particularly in the heart. The fragmentation pattern at Lys48 suggests the involvement of a serine protease, such as plasmin. The mos...
Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk
Miranda-Gonçalves, Vera; Bezerra, Filipa; Costa-Almeida, Raquel; Freitas-Cunha, Marta; Soares, Raquel; Martinho, Olga; Reis, R. M.; Pinheiro, CélineGlioblastoma (GBM) is one of the most glycolytic and angiogenic human tumors, characteristics that contribute to the poor prognosis associated with this type of tumor. A lactate shuttle has been described between tumor cells and endothelial cells (ECs), with the monocarboxylate transporters (MCTs) acting as important players in this tumor-EC communication. In this study, we aimed to understand how the tumor mic...