10 documents found, page 1 of 1
Co-expression network of neural-differentiation genes shows specific pattern in...
Maschietto, Mariana; Tahira, Ana C.; Puga, Renato; Lima, Leandro; Mariani, Daniel; Paulsen, Bruna da Silveira; Belmonte-de-Abreu, PauloBackground: Schizophrenia is a neurodevelopmental disorder with genetic and environmental factors contributing to its pathogenesis, although the mechanism is unknown due to the difficulties in accessing diseased tissue during human neurodevelopment. The aim of this study was to find neuronal differentiation genes disrupted in schizophrenia and to evaluate those genes in post-mortem brain tissues from schizophre...
Innate immune response is differentially dysregulated between bipolar disease a...
Baumont, Angelica de; Maschietto, Mariana; Lima, Leandro; Carraro, Dirce Maria; Olivieri, Eloisa Helena; Fiorini, Alex; Barreta, Luiz André NardinSchizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric conditions with a neurodevelopmental component. Genetic findings indicate the existence of an overlap in genetic susceptibility across the disorders. Also, image studies provide evidence for a shared neurobiological basis, contributing to a dimensional diagnostic approach. This study aimed to identify the molecular mechanisms that differentiate...
Gene expression of peripheral blood lymphocytes may discriminate patients with ...
Palha, Joana Almeida; Maschietto, Mariana; Silva, Aderbal R.; Puga, Renato; Lima, Leandro; Pereira, Carlos B.; Nakano, Eduardo Y.; Mello, BarbaraTo identify a classifier in schizophrenia, blood gene expression profiling was applied to patients with schizophrenia under different treatments and to controls. Expression of six genes discriminated patients with sensitivity of 89.3% and specificity of 90%, supporting the use of peripheral blood as biological material for diagnosis in schizophrenia.
Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevan...
Palha, Joana Almeida; Santos, Nadine Correia; Marques, Fernanda Cristina Gomes de Sousa; Sousa, João; Bessa, João; Miguelote, Rui; Sousa, NunoSchizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that ...
Transthyretin: No association between serum levels or gene variants and schizop...
Ruano, Dina; Macedo, António; Soares, Maria J.; Valente, José; Azevedo, Maria H.; Hutz, Mara H.; Gama, Clarissa S.; Lobato, Maria I.It has been proposed that schizophrenia results from an environmental insult in genetically predisposed individuals. Environmental factors capable of modulating transcriptional activity and their carriers could link the genetic and environmental components of schizophrenia. Among these is transthyretin (TTR), a major carrier of thyroid hormones and retinol-binding protein (RBP). Retinoids and thyroid hormones r...
Family-based and case-control studies reveal no association of lipocalin-type p...
Ruano, Dina; Macedo, António; Soares, Maria João; Valente, José; Azevedo, Maria Helena; Pato, Carlos; Hutz, Mara Helena; Gama, Clarissa S.Several observations point to the involvement of disturbed lipid biology in schizophrenia. Reduced response to niacin flushing test, which involves vasodilatation induced by prostaglandin D2 (PGD2), is among the evidences, together with decreased CSF levels of lipocalin-type prostaglandin D2 synthase (PTGDS), the enzyme responsible for the synthesis of PGD2 in the brain. Since PTGDS is also a carrier for lipoph...
Transthyretin: no association between serum levels or gene variants and schizop...
Ruano, Dina; Macedo, António; Soares, Maria J.; Valente, José; Azevedo, Maria H.; Hutz, Mara H.; Gama, Clarissa S.; Lobato, Maria I.It has been proposed that schizophrenia results from an environmental insult in genetically predisposed individuals. Environmental factors capable of modulating transcriptional activity and their carriers could link the genetic and environmental components of schizophrenia. Among these is transthyretin (TTR), a major carrier of thyroid hormones and retinol-binding protein (RBP). Retinoids and thyroid hormones r...
Ganho de peso e alterações metabólicas em esquizofrenia
Leitão-Azevedo, Carmem Lucia; Guimarães, Lísia Rejane; Lobato, Maria Inês; Belmonte-de-Abreu, PauloBACKGROUND: Five decades after use and dissemination of use of drugs for the treatment of schizophrenia, with different pharmacologic profiles, it has been evidenced that these drugs display a large profile of adverse events other than endocrinological and neurological, including weight gain, metabolic disorders, increased frequency of cardiovascular disorders and premature death associated to common disorders....
NR4A2 and schizophrenia: Lack of association in a Portuguese/Brazilian study
Ruano, Dina; Macedo, António; Dourado, Ana; Soares, Maria João; Valente, José; Coelho, Isabel; Santos, Vítor; Azevedo, Maria Helena; Goodman, AnnThe present study investigates the association of mutations in the nuclear receptor NR4A2 in schizophrenic patients. The human Nur-related receptor 1, NR4A2, is an orphan nuclear receptor that can be constitutively active as a transcription factor and for which no natural ligand has yet been identified. Alone or with retinoid X receptor, RXR, NR4A2 influences the expression of several genes important for human ...
NR4A2 and schizophrenia: lack of association in a portuguese/brazilian study
Ruano, Dina; Macedo, António; Dourado, Ana; Soares, Maria João; Valente, José; Coelho, Isabel; Santos, Vítor; Azevedo, Maria Helena; Goodman, AnnThe present study investigates the association of mutations in the nuclear receptor NR4A2 in schizophrenic patients. The human Nur-related receptor 1, NR4A2, is an orphan nuclear receptor that can be constitutively active as a transcription factor and for which no natural ligand has yet been identified. Alone or with retinoid X receptor, RXR, NR4A2 influences the expression of several genes important for human ...