4 documents found, page 1 of 1
22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma ...
Aranha, Elenn Suzany Pereira; Portilho, Adrhyann Jullyanne de Sousa; Sousa, Leilane Bentes de; Silva, Emerson Lucena da; Mesquita, Felipe PantojaEthnopharmacological relevance: 22β-hydroxytingenone (22-HTG) is a quinonemethide triterpene isolated from Salacia impressifolia (Miers) A. C. Smith (family Celastraceae), which has been used in traditional medicine to treat a variety of diseases, including dengue, renal infections, rheumatism and cancer. However, the anticancer effects of 22-HTG and the underlying molecular mechanisms in melanoma cells have no...
AURKA, MAPK14 e genes da via MTOR-MYC-E2F como novos potenciais biomarcadores t...
Mesquita, Felipe PantojaGastric cancer is one of the cancer types with the highest incidence and mortality rate in Brazil, especially in the north and northeast of the country, being considered an important public health issue not only in Brazil, but in other countries around the world as well. The treatment of this disease is increasingly restricted and facing problems such as chemoresistance in therapy with currently used chemothera...
Análise in silico da farmacocinética e farmacodinâmica do composto benzotiazóli...
Mesquita, Felipe Pantoja; Lima, Luina Benevides; Daniel, Julio Paulino; Portilho, Adrhyann Jullyanne de Sousa; Oliveira, Lais Lacerda Brasil deGastric adenocarcinoma has high incidence and mortality rates worldwide. The aim of this study was to evaluate the antitumor activity of benzothiazole AFN01 against ACP03 gastric adenocarcinoma cell line. Furthermore, computational prediction of the pharmacokinetics and pharmacodynamics of this molecule and the molecular docking with the relevant pharmacological target found were performed. The MTT assay was pe...
Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell ...
Pinto, Laine Celestino; Mesquita, Felipe Pantoja; Soares, Bruno Moreira; Silva, Emerson Lucena da; Puty, Bruna; Oliveira, Edivaldo Herculano Correa deFederal University of Par?. Biological Science Institute. Laboratory of Experimental Neuropathology. Bel?m, PA, Brazil.; Federal University of Cear?. Drug Research and Development Center. Laboratory of Pharmacogenetics. Fortaleza, CE, Brazil.; Federal University of Par?. Biological Science Institute. Laboratory of Human Cytogenetics. Bel?m, PA, Brazil.; Federal University of Cear?. Drug Research and Development...