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Dramatic secukinumab-mediated improvements in refractory leprosy-related neurit...
Kurizky,Patrícia Shu; Motta,Jorgeth de Oliveira Carneiro da; Bezerra,Natanael Victor Furtunato; Sousa,Marcia Carolline dos Santos; Corazza,DaniloAbstract A 39-year-old woman was diagnosed with relapsed multibacillary leprosy and refractory neuritis. Here, we describe an evident loss of therapeutic effectiveness after the third pulse of corticosteroids, which may be attributed to tachyphylaxis and the posterior modulation of interferon- γ (IFN-γ), tumor necrosis factor- α (TNF-α,) interleukin-17A (IL-17A), and IL-12/23p40 after the induction phase of sec...
Data: 2021
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Origem: Oasisbr