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Cyclosporin safety in a simplified rat brain tumor implantation model
Felix,Francisco H. C.; Fontenele,Juvenia B.; Teles,Milena G.; Bezerra Neto,João E.; Santiago,Márcia H. A. M.; Picanço Filho,Roberto L.Brain cancer is the second neurological cause of death. A simplified animal brain tumor model using W256 (carcinoma 256, Walker) cell line was developed to permit the testing of novel treatment modalities. Wistar rats had a cell tumor solution inoculated stereotactically in the basal ganglia (right subfrontal caudate). This model yielded tumor growth in 95% of the animals, and showed absence of extracranial met...
Date: 2012
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Origin: Oasisbr