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A circuit from hippocampal CA2 to lateral septum disinhibits social aggression
Leroy, Felix; Park, Jung; Asok, Arun; Brann, David H; Meira, Torcato Duarte Novo; Boyle, Lara M; Buss, Eric W; Kandel, Eric R; Siegelbaum, Steven AAlthough the hippocampus is known to be important for declarative memory, it is less clear how hippocampal output regulates motivated behaviours, such as social aggression. Here we report that pyramidal neurons in the CA2 region of the hippocampus, which are important for social memory, promote social aggression in mice. This action depends on output from CA2 to the lateral septum, which is selectively enhanced...
A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social mem...
Meira, Torcato Duarte Novo; Leroy, Felix; Buss, Eric W.; Oliva, Azahara; Park, Jung; Siegelbaum, Steven A.Recent results suggest that social memory requires the dorsal hippocampal CA2 region as well as a subset of ventral CA1 neurons. However, it is unclear whether dorsal CA2 and ventral CA1 represent parallel or sequential circuits. Moreover, because evidence implicating CA2 in social memory comes largely from long-term inactivation experiments, the dynamic role of CA2 in social memory remains unclear. Here, we us...