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Evaluation of T-NGS, Xpert Ultra, and Line Probe Assay on Clinical Samples for ...

Bhering, Marcela; Ribeiro, Eunice Petris; Silveira, Anna Karla; Lalucha, Carolyne; Ribeiro, Elizabete Oliveira; Igreja, Tathiany; Pôrto, Luís Cristóvão

Background: The rapid detection of drug resistance in Mycobacterium tuberculosis is essential for managing drug-resistant tuberculosis (DR-TB). This study evaluated the performance of molecular assays compared to phenotypic drug susceptibility testing (pDST) and targeted next-generation sequencing (T-NGS). Methods: We retrospectively analyzed 40 presumptive pulmonary DR-TB cases in Rio de Janeiro from 2018 to 2...


Effect of social, economic and health system aspects on the diagnostic and ther...

Bhering, Marcela; Kritski, Afranio

Introduction: State of Rio de Janeiro (ERJ) and District of Lisbon (DL) have a high concentration of cases of drug-resistant tuberculosis (DR-TB). Objectives: To compare the Epidemiological Surveillance of multidrug-resistant (MDR) TB in ERJ and DL, in order to understand the differences and similarities. Methods: Retrospective study with a quantitative and qualitative approach. MDR-TB data were extracted from ...


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