15 documents found, page 1 of 2
Computational and experimental advances in liver-on-a-chip technology for cance...
Carvalho, Violeta Meneses; Ferreira, Mariana; Rodrigues, Raquel O.; Teixeira, S. F. C. F.; Lima, Rui A.The integration of numerical simulations with Liver-on-a-Chip (LoC) technology ofers an innovative approach for studying liver physiology and pathology, especially in the context of liver cancer. Numerical simulations facilitate the optimization of microfuidic devices’ design and deepen the understanding of fuid fow and mass transfer. However, despite signifcant advancements, challenges such as replicating the ...
Numerical evaluation and experimental validation of fluid flow behavior within ...
Carvalho, Violeta Meneses; Gonçalves, Inês M.; Rodrigues, Nelson; Sousa, Paulo; Pinto, Vânia; Minas, Graça; Kaji, Hirokazu; Shin, Su RyonBy combining biomaterials, cell culture, and microfluidic technology, organ-on-a-chip (OoC) platforms have the ability to reproduce the physiological microenvironment of human organs. For this reason, these advanced microfluidic devices have been used to resemble various diseases and investigate novel treatments. In addition to the experimental assessment, numerical studies of biodevices have been performed aim...
Advancing blood-brain barrier-on-a-chip models through numerical simulations
Carvalho, Violeta Meneses; Rodrigues, Raquel O.; Shin, Su Ryon; Lima, Rui; Teixeira, S. F. C. F.Researchers have placed engineered or natural tissues within microfuidic chips originating the so-called organ-on-a-chip (OoC) devices. With this technology, organ models can be subjected to phenomena that replicate the complex in vivo biological environment. Furthermore, the OoC devices constitute a more valuable, cost-efective and ethical option when compared to assays performed in animal models for disease r...
Development of pH-Sensitive magnetoliposomes containing shape anisotropic nanop...
Pacheco, Ana Rita F.; Cardoso, Beatriz D.; Pires, Ana; Pereira, André M.; Araújo, João P.; Carvalho, Violeta M.; Rodrigues, Raquel O.Late diagnosis and systemic toxicity associated with conventional treatments make oncological therapy significantly difficult. In this context, nanomedicine emerges as a new approach in the prevention, diagnosis and treatment of cancer. In this work, pH-sensitive solid magnetoliposomes (SMLs) were developed for controlled release of the chemotherapeutic drug doxorubicin (DOX). Shape anisotropic magnetic nanopar...
Blood cells separation and sorting techniques of passive microfluidic devices: ...
Catarino, Susana O.; Rodrigues, Raquel O.; Pinho, Diana; Miranda, João M.; Minas, Graça; Lima, Rui Alberto Madeira MacedoSince the first microfluidic device was developed more than three decades ago, microfluidics is seen as a technology that exhibits unique features to provide a significant change in the way that modern biology is performed. Blood and blood cells are recognized as important biomarkers of many diseases. Taken advantage of microfluidics assets, changes on blood cell physicochemical properties can be used for fast ...
A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanopar...
Rodrigues, Raquel O.; Baldi, Giovanni; Doumett, Saer; Gallo, Juan; Bañobre-López, Manuel; Dražić, Goran; Calhelha, Ricardo C.; Ferreira, Isabel C. F. R.A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-dema...
Deformation of red blood cells, air bubbles, and droplets in microfluidic devic...
Bento, David; Rodrigues, Raquel O.; Faustino, Vera; Pinho, Diana; Fernandes, Carla S.; Pereira, Ana I.; Garcia, Valdemar; Miranda, João M.Techniques, such as micropipette aspiration and optical tweezers, are widely used to measure cell mechanical properties, but are generally labor-intensive and time-consuming, typically involving a difficult process of manipulation. In the past two decades, a large number of microfluidic devices have been developed due to the advantages they offer over other techniques, including transparency for direct optical ...
Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia ...
Rodrigues, Raquel O.; Baldi, Giovanni; Doumett, Saer; Garcia-Hevia, Lorena; Gallo, Juan; Bañobre-López, Manuel; Dražić, Goran; Calhelha, Ricardo C.The synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform ...
Red blood cells radial dispersion in blood flowing through microchannels: the r...
Pinho, Diana; Rodrigues, Raquel O.; Faustino, Vera; Yaginuma, T.; Exposto, José; Lima, Rui Alberto Madeira MacedoThe behavior of suspensions of individual blood cells, such as red blood cells (RBCs), flowing through microvessels and microfluidic systems depend strongly on the hematocrit (Hct), microvessel topology and cell properties. Although it is well known that blood rheological properties are temperature dependent, to the best of our knowledge no work has studied the role of the temperature on the RBCs dispersion. A ...
Wall expansion assessment of an intracranial aneurysm model by a 3D digital ima...
Rodrigues, Raquel O.; Pinho, Diana; Bento, D.; Lima, Rui Alberto Madeira Macedo; Ribeiro, JoãoIntracranial aneurysm is a local dilatation of an intracranial artery with high risk of rupture and death. Although it is generally accepted that the weakening of the arterial wall is the main cause for the rupture of an aneurysm, it still no consensus about the reasons for its creation, expansion and rupture. In particular, what is the role played by the blood flow in these phenomena. In this way, the aim of t...