10 documents found, page 1 of 1
Comparative study of humoral and cellular immunity against SARS-CoV-2 induced b...
Hasan, Zahra; Masood, Kiran Iqbal; Qaiser, Shama; Kanji, Akbar; Mwenda, Fridah; Alenquer, Marta; Iqbal, Junaid; Ferreira, Filipe; Wassan, YaqubWe investigated the effectiveness of different COVID-19 vaccinations administered in Pakistan by studying the effect of inactivated virus, mRNA and vector formulations. This study in 916 participants was conducted between October 2021 and July 2022. Subjects receiving inactivated (A), mRNA (B), one-dose vector (C), and two-dose vector (D) vaccines were sampled at baseline, 6, 12, and 24 weeks. Serum IgG antibod...
Pre-existing IgG antibodies to HCoVs NL63 and OC43 spike increased during the p...
Hasan, Zahra; Masood, Kiran Iqbal; Veldhoen, Marc; Qaiser, Shama; Alenquer, Marta; Akhtar, Mishgan; Balouch, Sadaf; Iqbal, Junaid; Wassan, YaqubPreexisting immunity may be associated with increased protection against non-related pathogens such as, SARS-CoV-2. There is little information regarding endemic human coronaviruses (HCOVs) from Pakistan, which experienced a relatively low COVID-19 morbidity and mortality. We investigated antibodies to SARS-CoV-2 and HCoVs NL63 and OC43, comparing sera from prepandemic controls (PPC) period with responses in he...
Humoral and T cell responses to SARS-CoV-2 reveal insights into immunity during...
Masood, Kiran Iqbal; Qaiser, Shama; Abidi, Syed Hani; Khan, Erum; Mahmood, Syed Faisal; Hussain, Areeba; Ghous, Zara; Imtiaz, Khekahsan; Ali, NatashaBackground: Protection against SARS-CoV-2 is mediated by humoral and T cell responses. Pakistan faced relatively low morbidity and mortality from COVID-19 through the pandemic. To examine the role of prior immunity in the population, we studied IgG antibody response levels, virus neutralizing activity and T cell reactivity to Spike protein in a healthy control group (HG) as compared with COVID-19 cases and indi...
Investigating the impact of prior COVID-19 on IgG antibody and interferon γ res...
Hasan, Zahra; Masood, Kiran Iqbal; Qaiser, Shama; Khan, Erum; Hussain, Areeba; Ghous, Zara; Khan, Unab; Yameen, Maliha; Hassan, ImranBackground and Aims: COVID-19 vaccinations have reduced morbidity and mortality from the disease. Antibodies against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) have been associated with immune protection. Seroprevalence studies revealed high immunoglobulin G (IgG) antibody levels to SARS-CoV-2 in the Pakistani population before vaccinations. We investigated the effect of BBIBP-CorV vaccination...
Heterogeneous contributions of change in population distribution of body mass i...
Iurilli, Maria L. C.; Zhou, Bin; Bennett, James E.; Carrillo-Larco, Rodrigo M.; Sophiea, Marisa K.; Rodriguez-Martinez, Andrea; Bixby, HonorMade available in DSpace on 2022-04-28T19:30:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01; From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of ...
Heterogeneous contributions of change in population distribution of body mass i...
Iurilli, Maria L. C.; Zhou, Bin; Bennett, James E.; Carrillo-Larco, Rodrigo M.; Sophiea, Marisa K.; Rodriguez-Martinez, Andrea; Bixby, HonorMade available in DSpace on 2021-06-25T15:08:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-09; Wellcome Trust; From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in th...
Worldwide trends in body-mass index, underweight, overweight, and obesity from ...
Ezzati, Majid; Bentham, James; Di Cesare, Mariachiara; Bilano, Ver; Bixby, Honor; Zhou, Bin; Stevens, Gretchen A.; Riley, Leanne M.; Taddei, CristinaMade available in DSpace on 2018-11-26T20:04:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-12-16; Wellcome Trust; AstraZeneca; Background Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cove...
Epidemiology of enteroaggregative Escherichia coli infections and associated ou...
Rogawski, Elizabeth T.; Guerrant, Richard L.; Havt, Alexandre; Lima, Ila F. N.; Medeiros, Pedro H. Q. S.; Seidman, Jessica C.; McCormick, Benjamin J. J.Background Enteroaggregative E. coli (EAEC) have been associated with mildly inflammatory diarrhea in outbreaks and in travelers and have been increasingly recognized as enteric pathogens in young children with and without overt diarrhea. We examined the risk factors for EAEC infections and their associations with environmental enteropathy biomarkers and growth outcomes over the first two years of life in eight...
Use of antibiotics in children younger than two years in eight countries : a pr...
Rogawski, Elizabeth T.; Platts-Mills, James A.; Seidman, Jessica C.; John, Sushil; Mahfuz, Mustafa; Ulak, Manjeswori; Shrestha, Sanjaya K.Objective To describe the frequency and factors associated with antibiotic use in early childhood, and estimate the proportion of diarrhoea and respiratory illnesses episodes treated with antibiotics. Methods Between 2009 and 2014, we followed 2134 children from eight sites in Bangladesh, Brazil, India, Nepal, Pakistan, Peru, South Africa and the United Republic of Tanzania, enrolled in the MAL-ED birth cohort ...
Worldwide trends in body-mass index, underweight, overweight, and obesity from ...
Abarca-Gómez, Leandra; Abdeen, Ziad A~.; Hamid, Zargar Abdul; Abu-Rmeileh, Niveen M.; Acosta-Cazares, Benjamin; Acuin, Cecilia; Adams, Robert J.Background Underweight, overweight, and obesity in childhood and adolescence are associated with adverse health consequences throughout the life-course. Our aim was to estimate worldwide trends in mean body-mass index (BMI) and a comprehensive set of BMI categories that cover underweight to obesity in children and adolescents, and to compare trends with those of adults. Methods We pooled 2416 population-based s...