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Decision-Making for Endovascular Thrombectomy in Patients With Large Vessel Occ...

Bosshart, Salome L; Kappelhof, Manon; Stebner, Alexander; Fujiwara, Satoru; Cimflova, Petra; Schüngel, Marie-Sophie; Milot, Genevieve

Acute ischemic stroke patients with mild deficits (National Institutes of Health Stroke Scale [NIHSS] of 0-5) but confirmed large vessel occlusions (LVO) present a clinical challenge for endovascular thrombectomy (EVT) decisions due to limited evidence and the absence of clear guidelines. A Delphi consensus was conducted at the 2024 5T (Teamwork, Training, Technology, Technique, Transport) Think Tank conference...


Framework for clinical trials in cerebral small vessel disease (FINESSE)

Markus, Hugh S.; van Der Flier, Wiesje M.; Smith, Eric E.; Bath, Philip; Biessels, Geert Jan; Briceno, Emily; Brodtman, Amy; Chabriat, Hugues

Importance: Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology. Disease mechanisms in SVD differ from other stroke etiologies; therefore, treatments need to be evaluated in cohorts in which SVD has been well characterized. Furthermore, SV...


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