4 documents found, page 1 of 1
Anti-Tumor Efficiency of Perillylalcohol/β-Cyclodextrin Inclusion Complexes in ...
Rezende, Allan A.; Santos, Rafael S.; Andrade, Luciana N.; Amaral, Ricardo G.; Pereira, Matheus M.; Bani, Cristiane; Chen, Mo; Priefer, RonnyThe low solubility and high volatility of perillyl alcohol (POH) compromise its bioavailability and potential use as chemotherapeutic drug. In this work, we have evaluated the anticancer activity of POH complexed with β-cyclodextrin (β-CD) using three complexation approaches. Molecular docking suggests the hydrogen-bond between POH and β-cyclodextrin in molar proportion was 1:1. Thermal analysis and Fourier-tra...
Cymbopogon winterianus Essential Oil Attenuates Bleomycin-Induced Pulmonary Fib...
Tavares, Lívia A.; Rezende, Allan A.; Santos, Jymmys L.; Estevam, Charles S.; Silva, Ana M. O.; Schneider, Jaderson K.; Cunha, John L. S.The essential oil of Cymbopogon winterianus (EOCW) is a natural product with antioxidant, anti-inflammatory, and antifibrotic properties. We studied the effect of EOCW in the progression of histological changes of pulmonary fibrosis (PF) in a rodent model. The oil was obtained by hydrodistillation and characterized using gas chromatography-mass spectrometry. Intratracheal instillation of bleomycin was performed...
Cymbopogon winterianus essential oil attenuates bleomycin-induced pulmonary fib...
Tavares, Lívia A.; Rezende, Allan A.; Santos, Jymmys L.; Estevam, Charles S.; Silva, Ana M. O.; Schneider, Jaderson K.; Cunha, John L. S.The essential oil of Cymbopogon winterianus (EOCW) is a natural product with antioxidant, anti-inflammatory, and antifibrotic properties. We studied the effect of EOCW in the progression of histological changes of pulmonary fibrosis (PF) in a rodent model. The oil was obtained by hydrodistillation and characterized using gas chromatographymass spectrometry. Intratracheal instillation of bleomycin was performed ...
Anti-tumor efficiency of Perillylalcohol/β-Cyclodextrin inclusion complexes in ...
Rezende, Allan A.; Santos, Rafael S.; Andrade, Luciana N.; Amaral, Ricardo G.; Pereira, Matheus M.; Bani, Cristiane; Chen, Mo; Priefer, RonnyThe low solubility and high volatility of perillyl alcohol (POH) compromise its bioavailability and potential use as chemotherapeutic drug. In this work, we have evaluated the anticancer activity of POH complexed with -cyclodextrin (-CD) using three complexation approaches. Molecular docking suggests the hydrogen-bond between POH and -cyclodextrin in molar proportion was 1:1. Thermal analysis and Fourier-transf...