Encontrados 2 documentos, a visualizar página 1 de 1
In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol d...
Silva, Luiz Francisco Rocha e; Nogueira, Karla Lagos; Pinto, Ana Cristina da Silva; Katzin, Alejandro Miguel; Sussmann, Rodrigo Antonio Ceschini4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stability and significant in vitro antiplasmodial activity. The aim of this work was to study the in vitro inhibition of hemozoin formation, inhibition of isoprenoid biosynthesis in Plasmodium falciparum cultures, and in v...
In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon
Lima, Renata Braga Souza; Rocha Silva, Luiz F.; Melo, Márcia R.S.; Costa, Jacqueline S.; Picanço, Neila Soares; Lima, Emerson SilvaBackground: The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum and Plasmodium vivax drug-re...