3 documents found, page 1 of 1
Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy...
Souto, Selma B.; Campos, Joana R.; Fangueiro, Joana F.; Silva, Amélia M.; Cicero, Nicola; Lucarini, Massimo; Durazzo, Alessandra; Santini, AntonelloA major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia), resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause diabetic vasculopathy, a secondary systemic damage. C-Peptide is a product of cleavage of proinsulin by a serine protease that occurs within the pancreatic -cells, being secreted in similar amounts as insulin. The biological activity of human ...
Spouted bed dried Rosmarinus officinalis extract: a novel approach for physicoc...
Souza, Claudia R. F.; Baldim, Iara; Bankole, Victor O.; da Ana, Raquel; Durazzo, Alessandra; Lucarini, Massimo; Cicero, Nicola; Santini, AntonelloIn this study, a conical-cylindrical spouted bed dryer with Teflon® beads as spouting material was used for producing powdered rosemary (Rosmarinus officinalis L.) extract. The influence of the inlet drying gas temperature (Tgi) and the percentage ratio between the feed rate of concentrated liquid extract by the maximum evaporation capacity of the spouted bed (Ws/Wmax) on selected physicochemical properties of ...
Development and optimization of alpha-pinene-loaded solid lipid nanoparticles (...
Zielinska, Aleksandra; Ferreira, Nuno R.; Durazzo, Alessandra; Lucarini, Massimo; Cicero, Nicola; Mamouni, Soukaina El; Silva, Amélia M.; Nowak, IzabelaThe encapsulation of bicyclic monoterpene α-pinene into solid lipid nanoparticles (SLN) is reported using experimental factorial design, followed by high-end dispersion analyzer LUMiSizer®. This equipment allows the characterization of the α-pinene-loaded SLN instability phenomena (e.g., sedimentation, flotation or coagulation), as well as the determination of the velocity distribution in the centrifugal field ...