9 documents found, page 1 of 1
Evaluation of the Efficacy of the SARS-CoV-2 Vaccine Additional and Booster Dos...
Ladeira, Filipa; Nobrega, Claudia; Cerqueira, JoãoStudies evaluating COVID-19 primary vaccination with two vaccines reported a blunt response in Multiple Sclerosis (MS) patients under anti-CD20 and sphingosine-1-phosphate (S1P) modulators. An extended primary vaccination (EPV) was recommended in immunosuppressed MS patients. Data on the effectiveness of the EPV and subsequent booster dose are limited. A prospective cohort study (n = 270) was conducted to evalu...
People with primary progressive multiple sclerosis have a lower number of centr...
Gomes, João Manuel Canto; Da Silva-Ferreira, Sara; Silva, Carolina S.; Boleixa, Daniela; Martins da Silva, Ana; González-Suárez, InésThe importance of circulating immune cells to primary progressive multiple sclerosis (PPMS) pathophysiology is still controversial because most immunotherapies were shown to be ineffective in treating people with PPMS (pwPPMS). Yet, although controversial, data exist describing peripheral immune system alterations in pwPPMS. This study aims to investigate which alterations might be present in pwPPMS free of dis...
Thymic function as a predictor of immune recovery in chronically HIV-infected p...
Rb-Silva, Rita; Nobrega, Claudia; Azevedo, Cecilia; Athayde, Emilia; Canto-Gomes, João; Ferreira, Ivo; Cheynier, Rémi; Yates, Andrew J.; Horta, AnaPoor immunological responders (PIR) are HIV-infected patients with virologic suppression upon antiretroviral therapy (ART) but persistently low CD4+ T cell counts. Early identification of PIR is important given their higher morbimortality compared to adequate immune responders (AIR). In this study, 33 patients severely lymphopenic at ART onset, were followed for at least 36 months, and classified as PIR or AIR ...
Immune Thymic Profile of the MOG-Induced Experimental Autoimmune Encephalomyeli...
Neves, Sofia Pereira; Miranda, Cláudia Sofia Serre; Nobrega, Claudia; Roque, Susana; Cerqueira, João José; Correia-Neves, M; Marques, FernandaMultiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease that affects the neurons of the central nervous system. Activated T cells, specific for myelin epitopes, cross the brain barriers, and react against the myelin sheath, leading to demyelination. Since T cells are generated within the thymus, here we explored, in mice, the alterations occurring in this organ throughout the different phas...
Longitudinal evaluation of regulatory T-cell dynamics on HIV-infected individua...
Nobrega, Claudia; Horta, Ana Maria Lacerda Morgado Fernandes Carvalho Aboim; Teixeira, Vítor Emanuel Coutinho; Martins-Ribeiro, AnaObjectives: A sizeable percentage of individuals infected by HIV and on antiretroviral therapy (ART) fail to increase their CD4+ T-cells to satisfactory levels. The percentage of regulatory T-cells (Tregs) has been suggested to contribute to this impairment. This study aimed to address this question and to expand the analysis of Tregs subpopulations during ART. Design: Longitudinal follow-up of 81 HIV-infected ...
Environmental enrichment does not compromise the immune response in mice chroni...
Olsson, I. A. S.; Costa, A.; Nobrega, Claudia; Roque, Susana; Correia-Neves, MResearch on infectious diseases using animal models has been a successful example of translational research. However, because chronic infections are still one of the main causes of death and disability in the world, it is expected that a great number of mice will continue to be used to address this subject. Although increasing awareness regarding animal welfare has led to novel recommendations for animal housin...
Dissemination of mycobacteria to the thymus renders newly generated T cells tol...
Nobrega, Claudia; Roque, Susana; Nunes-Alves, Cláudio; Coelho, Angela; Medeiros, Irene; Castro, António G.; Appelberg, Rui; Correia-Neves, MThe ability of the thymus to generate a population of T cells that is, for the most part, self-restricted and self-tolerant depends to a great extent on the Ags encountered during differentiation. We recently showed that mycobacteria disseminate to the thymus, which raised the questions of how mycobacteria within the thymus influence T cell differentiation and whether such an effect impacts host-pathogen intera...
IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacte...
Roque, Susana; Nobrega, Claudia; Appelberg, Rui; Correia-Neves, MIncreased production of IL-10 has been frequently associated with augmented susceptibility to infection. However, the correlation between IL-10 activity and susceptibility to mycobacterial infection is still uncertain. Although studies using transgenic mice overexpressing IL-10 consistently showed an increased susceptibility to mycobacterial infection, experimental approaches in which IL-10 activity was reduced...
The thymus as a target for mycobacterial infections
Nobrega, Claudia; Cardona, Pere-Joan; Roque, Susana; Pinto do Ó, Perpétua; Appelberg, Rui; Correia-Neves, M.Mycobacterial infections are among the major health threats worldwide. Ability to fight these infections depends on the host's immune response, particularly on macrophages and T lymphocytes produced by the thymus. Using the mouse as a model, and two different routes of infection (aerogenic or intravenous), we show that the thymus is consistently colonized by Mycobacterium tuberculosis, Mycobacterium avium or My...