5 documents found, page 1 of 1
Unveiling the agonistic properties of Preyssler-type Polyoxotungstates on purin...
Poejo, Joana; Gumerova, Nadiia I.; Rompel, Annette; Mata, Ana M.; Aureliano, Manuel; Gutierrez-Merino, CarlosThe Preyssler-type polyoxotungstate ({P5W30}) belongs to the family of polyanionic metal-oxides formed by group V and VI metal ions, such as V, Mo and W, commonly known as polyoxometalates (POMs). POMs have demonstrated inhibitory effect on a significant number of ATP-binding proteins in vitro. Purinergic P2 receptors, widely expressed in eukaryotic cells, contain extracellularly oriented ATP-binding sites and ...
Congenital disorders of glycosylation (CDG)
Francisco, Rita; Brasil, Sandra; Poejo, Joana; Jaeken, Jaak; Pascoal, Carlota; Videira, Paula A.; dos Reis Ferreira, VanessaCongenital disorders of glycosylation (CDG) are a complex and heterogeneous family of rare metabolic diseases. With a clinical history that dates back over 40 years, it was the recent multi-omics advances that mainly contributed to the fast-paced and encouraging developments in the field. However, much remains to be understood, with targeted therapies' discovery and approval being the most urgent unmet need. In...
Evaluating the effect of chitosan layer on bioaccessibility and cellular uptake...
Silva, Hélder D.; Beldikova, E.; Poejo, Joana; Abrunhosa, Luís; Serra, Ana Teresa; Duarte, Catarina M. M.; Brányik, TomáCurcumin nanoemulsions stabilized by whey protein isolate were successfully developed using high-pressure homogenization. The effect of a chitosan layer deposition using the layer-by-layer technique on nanoemulsions' stability was evaluated during storage conditions, as well as during gastrointestinal tract passage. Lipids hydrolysis and curcumin bioaccessibility was assessed using a dynamic gastrointestinal mo...
Evaluating the behaviour of curcumin nanoemulsions and multilayer nanoemulsions...
Silva, Hélder D.; Poejo, Joana; Pinheiro, Ana Cristina; Donsì, Francesco; Serra, Ana Teresa; Duarte, Catarina M. M.; Ferrari, GiovannaNanoemulsions can be used to improve the bioaccessibility of lipophilic bioactive compounds, such as curcumin, being their behaviour highly influenced by their interfacial properties. The effect of chitosan and alginate layers deposition on curcumin nanoemulsions behaviour during in vitro digestion was evaluated using a dynamic gastrointestinal system. Results showed that polyelectrolyte layers deposition impro...
Assessing the influence of a chitosan layer on curcumin nanoemulsions bioaccess...
Silva, Hélder Daniel Peixoto; Beldikova, E.; Poejo, Joana; Abrunhosa, Luís; Serra, Teresa; Duarte, Catarina M. M.; Brányik, Tomáš