2 documents found, page 1 of 1
Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6...
Pedrosa, AG; Francisco, T; Bicho, D; Dias, AF; Barros-Barbosa, A; Hagmann, V; Dodt, G; Rodrigues, TA; Azevedo, JEPEX1 and PEX6 are two members of the ATPases associated with diverse cellular activities (AAA) family and the core components of the receptor export module of the peroxisomal matrix protein import machinery. Their role is to extract monoubiquitinated PEX5, the peroxisomal protein-shuttling receptor, from the peroxisomal membrane docking/translocation module (DTM), so that a new cycle of protein transportation c...
Protein transport into peroxisomes: Knowns and unknowns
Francisco, T; Rodrigues, TA; Dias, AF; Barros-Barbosa, A; Bicho, D; Azevedo, JEPeroxisomal matrix proteins are synthesized on cytosolic ribosomes and rapidly transported into the organelle by a complex machinery. The data gathered in recent years suggest that this machinery operates through a syringe-like mechanism, in which the shuttling receptor PEX5 - the “plunger” - pushes a newly synthesized protein all the way through a peroxisomal transmembrane protein complex - the “barrel” - into...