26 documents found, page 1 of 3
Fetal Hemoglobin as a Predictive Biomarker for Retinopathy of Prematurity: A Pr...
Fevereiro-Martins, M; Aguiar, L; Inácio, Â; Cardoso, C; Santos, AC; Marques-Neves, C; Guimarães, H; Pinto, R; Bicho, MBackground/Objectives: Retinopathy of prematurity (ROP) is a leading cause of vision impairment in preterm infants, with its pathogenesis linked to oxygen exposure. Red blood cell (RBC) transfusions, commonly performed in neonatal intensive care units (NICUs), reduce fetal hemoglobin (HbF) fraction, altering oxygen dynamics and potentially contributing to ROP. We aimed to investigate the relationship between RB...
Influence of Functional Variations in Genes of Neurotrophins and Neurotransmitt...
Fevereiro-Martins, M; Santos, AC; Marques-Neves, C; Guimarães, H; Bicho, Mfirst_pagesettingsOrder Article Reprints Open AccessArticle Influence of Functional Variations in Genes of Neurotrophins and Neurotransmitter Systems on the Development of Retinopathy of Prematurity by Mariza Fevereiro-Martins 1,2,3,4,*,Ana Carolina Santos 1,2ORCID,Carlos Marques-Neves 1,2,5,Hercília Guimarães 6ORCID,Manuel Bicho 1,2,3ORCID andon behalf of the GenE-ROP Study Group † 1 Faculdade de Medicina, Uni...
Retinopathy of Prematurity in Eight Portuguese Neonatal Intensive Care Units: I...
Fevereiro-Martins, M; Santos, ACa; Marques-Neves, C; Bicho, M; Guimarães, HBackground/objectives: Retinopathy of prematurity (ROP) is a retinal neovascular disease affecting preterm infants. Identifying risk factors for its development and progression is critical for effective screening and prevention. This study aimed to analyze the incidence of ROP and identify key risk factors for its development and progression. Methods: We conducted a prospective, observational cohort study on 45...
Retinopathy of Prematurity in Eight Portuguese Neonatal Intensive Care Units: I...
Fevereiro-Martins, M; Santos, AC; Marques-Neves, C; Bicho, M; Guimarães, HBackground/Objectives: Retinopathy of prematurity (ROP) is a retinal neovascular disease affecting preterm infants. Identifying risk factors for its development and progression is critical for effective screening and prevention. This study aimed to analyze the incidence of ROP and identify key risk factors for its development and progression. Methods: We conducted a prospective, observational cohort study on 45...
Analysis of Genes Involved in Oxidative Stress and Iron Metabolism in Heart Fai...
Silva, PX; Aguiar, L; Gaspar, M; Faustino, P; Falcão, LM; Barbosa, M; Bicho, M; Inácio, ÂIntroduction: Heart failure (HF) is a clinical syndrome characterized by cardinal symptoms that may be accompanied by signs. It results from structural and/or functional abnormalities of the heart leading to elevated intracardiac pressures and/or inadequate cardiac output at rest and/or during exercise. The prevalence of iron deficiency and anemia justifies the current guidelines recommendation of screening. Ge...
Complete blood count parameters as biomarkers of retinopathy of prematurity: a ...
Fevereiro-Martins, M; Santos, AC; Marques-Neves, C; Guimarães, H; Bicho, M; Afonso, C; Ferreira, J; Espírito Santo, R; Teixeira, F; Rosa, RPurpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory d...
Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of ...
Fevereiro-Martins, M; Santos, AC; Marques-Neves, C; Guimarães, H; Bicho, MThe development of retinopathy of prematurity (ROP) may be influenced by anemia or a low fetal/adult hemoglobin ratio. We aimed to analyze the association between DNA methyltransferase 3 β (DNMT3B) (rs2424913), methylenetetrahydrofolate reductase (MTHFR) (rs1801133), and lysine-specific histone demethylase 1A (KDM1A) (rs7548692) polymorphisms, erythrocyte parameters during the first week of life, and ROP. In to...
Retinopathy of prematurity: contribution of inflammatory and genetic factors
Fevereiro-Martins, M; Guimarães, H; Marques-Neves, C; Bicho, MRetinopathy of prematurity (ROP) is a retinal vasoproliferative disorder that represents an important cause of childhood visual impairment and blindness. Although oxidative stress has long been implicated in ROP etiology, other prenatal and perinatal factors are also involved. This review focuses on current research involving inflammation and genetic factors in the pathogenesis of ROP. Increasing evidence sugge...
Retinopathy of prematurity: A review of pathophysiology and signaling pathways
Fevereiro-Martins, M; Marques-Neves, C; Guimarães, H; Bicho, MRetinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading cause of visual impairment and childhood blindness worldwide. The disease is characterized by an early stage of retinal microvascular degeneration, followed by neovascularization that can lead to subsequent retinal detachment and permanent visual loss. Several factors play a key role during the different pathological st...
Parámetros hematológicos descuidados en el pronóstico de la insuficiencia cardí...
Barbosa, M; Matos, A; Bicho, M; Falcão, LMAims: In heart failure patients, anemia and iron deficiency are predictors of poor outcome. We studied the association of anemia, iron deficiency and related hematological parameters with short-term rehospitalization, short-term all-cause mortality and end of follow-up all-cause mortality in heart failure patients. Material and Methods: Anemia, iron deficiency, red cell distribution width and erythropoietin wer...