8 documents found, page 1 of 1
The interplay between HPV, other sexually transmissible infections and genital ...
Gonçalves-Nobre, J. Guilherme; Matos, Andreia; Carreira, Mariana; Santos, Ana Carolina; Veiga, Luisa; Ginete, Catarina; Brito, Miguel; Pires, MarinaBackground: The importance of Cervicovaginal Microbiota in protecting against infections (such as HPV) is already well established, namely through Lactobacillus spp., as well as the mechanism through which HPV leads to Cervical Neoplasia. However, it is not possible to classify HPV as a complete carcinogen. Thus, the importance of exploring Cervicovaginal dysbiosis to decipher this interaction with HPV takes on...
The interplay between HPV, other sexually transmissible infections and genital ...
Gonçalves Nobre, José Guilherme; Matos, Andreia; Carreira, Mariana; Santos, Ana Carolina; Veiga, Luisa Carvalho; Ginete, Catarina; Brito, MiguelBackground: The importance of Cervicovaginal Microbiota in protecting against infections (such as HPV) is already well established, namely through Lactobacillus spp., as well as the mechanism through which HPV leads to Cervical Neoplasia. However, it is not possible to classify HPV as a complete carcinogen. Thus, the importance of exploring Cervicovaginal dysbiosis with the intention of deciphering this interac...
Leiomyoma and the importance of genetic variation on genes related to the vascu...
Inácio, Angela; Aguiar, Laura; Rodrigues, Beatriz; Pires, Patrícia; Ferreira, Joana; Bilhim, Tiago; Pisco, João; Bicho, Manuel; Bicho, Maria ClaraObjective: The link between the systemic vasculature system and tumor biology is here investigated by studying the contribution of CβS (844ins68), MTHFR (677C > T), NOS3 (4a/4b), CYBA (C242T), and ACE1 (I/D) genes to leiomyoma onset, uterus and leiomyoma volumes. Methods: DNA samples from 130 women with leiomyomas and 527 from healthy women were genotyped by PCR or PCR-RFLP. Qui-square (χ2) or Fisher's exact te...
Knowledge, attitudes and practices of cervical cancer screening among female st...
Rocha, Natalina Sousa Silva; Bicho, Maria Clara; Luz, Lima Mendonça M; Martins, Maria do Rosário OliveiraCervical cancer (CC) is the fourth most common cancer among women in the world and the second in Africa. CC is the third most frequent cancer and the first cause of cancer-related death among women in Cabo Verde, with an estimated incidence of 17 cases per 100,000 women. The mortality rate is around 10.5% and represents one of the largest percentages of all types of cancer diagnosed in women in the country. The...
Genetic modulation of HPV infection and cervical lesions: role of oxidative str...
Inácio, Angela; Aguiar, Laura; Rodrigues, Beatriz; Pires, Patrícia; Ferreira, Joana; Matos, Andreia; Mendonça, Inês; Rosa, Raquel; Bicho, ManuelHuman papillomavirus (HPV) infection is a necessary but not sufficient factor for the development of invasive cervical cancer (ICC) and high-grade intraepithelial lesion (HSIL). Oxidative stress is known to play a crucial role in HPV infection and carcinogenesis. In this study, we comprehensively investigate the modulation of HPV infection, HSIL and ICC, and ICC through an exploration of oxidative stress-relate...
Saúde ambiental : caderno de notas soltas III
Santos, Ricardo; Santos, Osvaldo; Abreu, Ana; Caminha, Luís; Costa, Andreia; Sul, Susana; Nogueira, Paulo Jorge; Henriques, Adriana; Arriaga, MiguelNa sua 3.ª edição, o Caderno de Notas Soltas pretende reunir diferentes perspetivas e metodologias, celebrando a sua razão de ser e a nobreza da sua génese intimamente ligada à realidade dos estudantes. Na verdade, passados três anos retomamos uma colaboração firmada desde a primeira hora com a Associação de Estudantes da Faculdade de Medicina de Lisboa (AEFML), num registo de proximidade da comunidade estudant...
Association of myeloperoxidase polymorphism (G463A) with cervix cancer
Castelão, Cindy; Silva, Alda Pereira da; Matos, Andreia; Inácio, Ângela; Bicho, Manuel; Medeiros, Rui; Bicho, Maria ClaraCervical cancer is the fourth most common cancer affecting women worldwide, according to the latest IARC release with 528 000 new cases every year. Infection by high-risk human papillomavirus (HPV) is necessary but not sufficient for progression to cancer. Epithelial tissues, the target of HPV infection, are heavily exposed to reactive oxygen species (ROS). Hypochlorous acid (HOCl) is a very potent ROS, and it ...
Biomarkers of Cervical Carcinogenesis Associated with Genital HPV Infection
Bicho, Maria Clara.; .