21 documents found, page 1 of 3

Integration of FTIR spectroscopy and machine learning for kidney allograft reje...

Kidney transplantation is a life-saving treatment for end-stage kidney disease, but allograft rejection remains a critical challenge, requiring accurate and timely diagnosis. The study aims to evaluate the integration of Fourier Transform Infrared (FTIR) spectroscopy and machine learning algorithms as a minimally invasive method to detect kidney allograft rejection and differentiate between T Cell-Mediated Reje...

Individualizing Treatment for CMV with UL97 del597-599 Mutation: Beyond Unusual...

Human cytomegalovirus (CMV) infection is the most prevalent infection affecting organ transplant recipients, and it is a cause of morbidity and mortality in patients undergoing kidney transplantation. The introduction of ganciclovir (GCV) for both prophylaxis and treatment has vastly improved patient outcomes. GCV resistance can be caused by mutations in the UL97 phosphotransferase gene or the UL54 polymerase g...

Custos e Consequências da Doença Renal Crónica em Pessoas com Diabetes em Portu...

Introduction: Chronic kidney disease is the fastest-growing chronic disease in terms of prevalence and one of the biggest causes of global mortality according to the Global Burden of Disease Collaboration. This study aimed to project the natural disease progression of this disease in people with diabetes, and to quantify the costs and consequences in the Portuguese context. This was achieved by developing an an...

Chronic Kidney Disease: a practical guide (ACT-NAU)

Integration of FTIR Spectroscopy and Machine Learning for Kidney Allograft Reje...

Publisher Copyright: © 2025 by the authors.; Background: Kidney transplantation is a life-saving treatment for end-stage kidney disease, but allograft rejection remains a critical challenge, requiring accurate and timely diagnosis. The study aims to evaluate the integration of Fourier Transform Infrared (FTIR) spectroscopy and machine learning algorithms as a minimally invasive method to detect kidney allograft...

Rapid FTIR Spectral Fingerprinting of Kidney Allograft Perfusion Fluids Disting...

Funding Information: This research was funded by Centro Cl\u00EDnico Acad\u00E9mico de Lisboa, grant number FF-CCAL.05.2025. Publisher Copyright: © 2025 by the authors.; Background/Objectives: Rapid, objective phenotyping of donor kidneys is needed to support peri-implant decisions. Label-free Fourier-transform infrared (FTIR) spectroscopy of static cold-storage Celsior® perfusion fluid can discriminate kidneys...

Risk Factors of Acute T‐Cell Mediated and Borderline Rejection Diagnosed in Ear...

Introduction: Acute graft rejection remains one of the main causes of graft dysfunction and premature loss. Under‐ standing the factors affecting graft rejection is essential to promote graft survival. Our study aimed to determine the incidence and assess risk factors of acute T‐cell mediated rejection (TCMR) and borderline rejection in early protocol kidney transplant biopsies. Methods: Retrospective single‐ce...

Doença renal crónica: um guia prático (ACT-NAU)

A doença renal crónica (DRC) é um importante problema de saúde pública que está associada ao aumento da morbimortalidade global e é um fator de risco significativo para a doença cardiovascular. A prevalência da DRC tem aumentado exponencialmente em todo o mundo. A sua prevalência em Portugal é de 20,9% nos estádios 1 a 5 da DRC e de 9,8% para os estádios ≥G3a/A1 da DRC, pelo que é de extrema importância que est...

NAU ‐ New NAU - Areas of Unifying Interest for CKD: A Multidisciplinary Expert ...

Introduction: The global prevalence of chronic kidney disease (CKD) is rising exponentially. While patient awareness of CKD remains low, we studied the physicians’ awareness and how globally it can be improved. We aimed to evaluate the awareness and consensus of physicians on the screening, diagnosis and clinical management of CKD, thus identifying which areas should be the subject of educational or research pr...

Risk Factors of Acute T‑Cell Mediated and Borderline Rejection Diagnosed in Ear...

Introduction: Acute graft rejection remains one of the main causes of graft dysfunction and premature loss. Understanding factors affecting graft rejection is essential to promote graft survival. Our study aimed to determine the incidence and assess risk factors of acute T‑cell mediated rejection (TCMR) and borderline rejection in early protocol kidney transplant biopsies. Methods: Retrospective single‑center s...