17 documents found, page 1 of 2
Factors influencing community intensive care unit research participation: a qua...
Gehrke, Paige; Rego, Kian; Orlando, Elaina; Jack, Susan; Law, Madelyn; Cook, Deborah; Marticorena, Rosa M.; Binnie, Alexandra; Tsang, Jennifer L. Y.Purpose Community hospitals account for 90% of hospitals in Canada, but clinical research is mainly conducted in academic hospitals. Increasing community hospital research participation can improve generalizability of study results, while also accelerating study recruitment and increasing staff engagement. We aimed to identify and describe the factors that influence community intensive care unit (ICU) research ...
Identification of novel DNA methylation prognostic biomarkers for AML with norm...
Cardoso, Cândida; Pestana, Daniel; Gokuladhas, Sreemol; Marreiros, Ana; Justin M. O'Sullivan; Binnie, Alexandra; Teotónio Fernandes, Mónica AlexandraPURPOSE AML is a hematologic cancer that is clinically heterogeneous, with a wide range of clinical outcomes. DNA methylation changes are a hallmark of AML but are not routinely used as a criterion for risk stratification. The aim of this study was to explore DNA methylation markers that could risk stratify patients with cytogenetically normal AML (CN-AML), currently classified as intermediate-risk.MATERIALS AN...
Community versus academic hospital community-acquired pneumonia patients: a nes...
Tsang, Jennifer L. Y.; Rego, Kian; Binnie, Alexandra; Binnie, Alexandra; Lee, Terry; Mccarthy, Anne; Cowan, Juthaporn; Archambault, PatrickBackground: Most Canadians receive their care in community hospitals, yet most clinical research is conducted in academic hospitals. This study aims to compare patients with community acquired pneumonia (CAP) treated in academic and community hospitals with respect to their demographics, clinical characteristics, treatments and outcomes. Methods This nested observational cohort substudy of the Community Acquire...
CO-5 Impact of interprofessional simulation on teamwork performance amongst med...
Silva Isidro, Michael; Binnie, Alexandra; Correia, André; Marta de Castro, Manuela; Farinha, Conceição; José, HelenaIntroduction: Effective collaboration and communication within interprofessional teams is critical for quality and safety in healthcare delivery. Teams that communicate effectively and provide mutual support have reduced potential for error, resulting in improved clinical performance. In 2019, the University of Algarve created an innovative interprofessional education program, designed to train all final-year m...
Measuring healthy ageing: current and future tools
Silva, Nádia; Rajado, Ana Teresa; Esteves, Filipa; Brito, David V.C.; Apolónio, Joana; Roberto, Vânia; Binnie, Alexandra; Araújo, Inês MariaHuman ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable functional deterioration. As the population of the world grows older, placing significant strain on social and healthcare resources, there is a growing need to identify reliable and easy-to-employ markers of healthy ageing for early detection of ageing trajectories and d...
The impact of small-group virtual patient simulator training on perceptions of ...
Mestre, André; Muster, Marek; El Adib, Ahmed Rhassane; Ösp Egilsdottir, Hugrun; Byermoen, Kirsten Røland; Padilha, José Miguel Santos CastroBackground: The COVID-19 pandemic has precipitated rapid changes in medical education to protect students and patients from the risk of infection. Virtual Patient Simulators (VPS) provide a simulated clinical environment in which students can interview and examine a patient, order tests and exams, prioritize interventions, and observe response to therapy, all with minimal risk to themselves and their patients. ...
The impact of small-group virtual patient simulator training on perceptions of ...
Mestre, André; Muster, Marek; El Adib, Ahmed Rhassane; Ösp Egilsdottir, Hugrun; Byermoen, Kirsten R.; Padilha, Miguel; Aguilar, Thania; Tabagari, NinoThe COVID-19 pandemic has precipitated rapid changes in medical education to protect students and patients from the risk of infection. Virtual Patient Simulators (VPS) provide a simulated clinical environment in which students can interview and examine a patient, order tests and exams, prioritize interventions, and observe response to therapy, all with minimal risk to themselves and their patients. Like high-fd...
COVID-19 research in critical care: the good, the bad, and the ugly
Salluh, Jorge I. F.; Arabi, Yaseen M.; Binnie, AlexandraThe extraordinary pace of research on coronavirus disease 2019 (COVID-19) has been one of the major success stories of the pandemic. Therapeutic trials involving thousands of patients, which usually take years to complete, have been reported in a matter of months. National and international registries and networks have reported on tens of thousands of patients in near real time. However, there have also been ma...
Twenty articles that critical care clinicians should read about COVID-19
Tsang, Jennifer L. Y.; Binnie, Alexandra; Fowler, Robert A.Infection with the severe acute respiratory syndrome coronavirus- 2 (SARS-CoV-2) was first identified in December 2019 and has since become a worldwide pandemic, challenging and sometimes overwhelming healthcare systems as well as causing more than a million deaths thus far. In just 10 months, over 80,000 indexed publications have appeared that reference SARS-CoV-2 and the associated Coronavirus disease 2019 (C...
CRISPR-based strategies in infectious disease diagnosis and therapy
Binnie, Alexandra; Fernandes, Emanuel; Almeida‑Lousada, Helder; De Mello, Ramon Andrade; Castelo-Branco, PedroCRISPR gene-editing technology has the potential to transform the diagnosis and treatment of infectious diseases, but most clinicians are unaware of its broad applicability. Derived from an ancient microbial defence system, these so-called "molecular scissors" enable precise gene editing with a low error rate. However, CRISPR systems can also be targeted against pathogenic DNA or RNA sequences. This potential i...