2 documents found, page 1 of 1
Refractory myasthenia gravis: Characteristics of a portuguese cohort
Santos, Ernestina; Bettencourt, Andreia; Duarte, Sara; Gabriel, Denis; Oliveira, Vanessa; da Silva, Ana Martins; Costa, Paulo Pinho; Lopes, CarlosIntroduction: Some myasthenia gravis (MG) patients are refractory to conventional treatments. Methods: To describe the clinical features of refractory MG (RMG) and explore the association with human leukocyte antigen HLA-DRB1 alleles, a cohort study of 114 consecutive MG patients was performed. Patients were classified as RMG based on predefined criteria. Results: Twenty-two patients were found to have RMG (19....
HLA and age of onset in myasthenia gravis
Santos, Ernestina; Bettencourt, Andreia; da Silva, Ana Martins; Boleixa, Daniela; Lopes, Dina; Brás, Sandra; Costa, Paulo Pinho E.; Lopes, CarlosThe aetiology of MG is unknown, but both genetic and environmental factors are important. Over the years association of MG with Human Leucocyte Antigens (HLA) has been described in different populations. We investigated a possible association between HLA-DRB1 alleles and age of onset in MG. One hundred and fourteen MG patients (82 females) and 282 control individuals (CP) were studied. Patients were classified ...