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Efeito protetor da fração protéica do látex de Calotropis procera na mucosite i...
Bitencourt, Flávio da SilveiraIntestinal mucositis (IM) is a side effect of irinotecan (CPT-11), which is used for the treatment of colorectal cancer. The incidence of IM associated with severe diarrhea is estimated to be approximately 25% in patients. However, the clinical management of these side effects is still partially ineffective. Calotropis procera is a plant found in Africa, Asia, and South America. In Brazil, it is abundant in the...
Side-effects of irinotecan (CPT-11), the clinically used drug for colon cancer ...
Alencar, Nylane Maria Nunes de; Bitencourt, Flávio da Silveira; Figueiredo, Ingrid Samantha Tavares de; Luz, Patrícia BastosIntestinal mucositis (IM) is the critical side effect of irinotecan (CPT-11), which is the front-line drug used for the treatment of colorectal cancer. This study aimed to evaluate the effectiveness of latex proteins (LP) from Calotropis procera to prevent IM and diarrhea in animals. Swiss mice were treated daily with saline or LP (1, 5, or 50 mg/kg, i.v.) 24 h prior to CTP-11 (75 mg/kg/4 days, i.p) and for add...
Estudo da atividade antiinflamatória e antinociceptiva da lectina isolada da al...
Bitencourt, Flávio da SilveiraLectins are (glyco)proteins that can recognize and reversibly bind to carbohydrates or other substances derived from sugars. They are found throughout animal and vegetal kingdoms. Hypnea cervicornis is a species of marine red algae found in Northeast of Brazil from which was isolated the lectin Hypnea cervicornis aglutinin (HCA), a polypeptide containing 90 amino acid residues (9193 Da) that binds especifically...