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The first five-year evaluation of cystic fibrosis neonatal screening program in...
Maciel,Léa Maria Zanini; Magalhães,Patrícia Künzle Ribeiro; Ciampo,Ieda Regina Lopes Del; Sousa,Maria Luísa Barato de; Fernandes,Maria Inez MachadoThe Hospital of the Ribeirão Preto Medical School, University of São Paulo is one of the three screening centers in São Paulo State, Brazil, and has included a test for cystic fibrosis (CF) since February 6, 2010, by a court order. We evaluated the first five years of this CF-newborn screening program. The original immunoreactive trypsinogen (IRT)/IRT screening protocol was adopted in Brazil. A total of 173,571...
Effects of drying and storage conditions on the stability of TSH in blood spots
Magalhães,Patrícia Künzle Ribeiro; Miranda,Carlos Henrique; Vilar,Fernando Crivelenti; Schmidt,André; Bittar,Roberta RodriguesABSTRACT Objective To evaluate the influence of sample drying and storage temperature on TSH stability in neonatal screening. Subjects and methods Blood samples from 29 adult volunteers as a surrogate for neonatal blood (10 with normal TSH, 9 with overt hypothyroid and 10 with subclinical hypothyroidism) were spotted on filter paper and dried at 22°C or 35°C for 3 hours. The samples were then stored at 22°C, -4...