2 documents found, page 1 of 1
Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mo...
Simão, M.; Camacho, A.; Ostertag, A.; Cohen-Solal, M.; Pinto, I.; Porto, G.; Hang Korng, E.; Cancela, M.Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood. The main objective of this study was to investigate the role of dietary iron on osteoporosis, using as biological model the Hfe-KO mice, which have a systemic iron overload. We showed that these mice show an increased susceptibility for developing a bone l...
Iron overload in a murine model of hereditary hemochromatosis is associated wit...
Camacho, A.; F. Simao, Marcio; Ea, H. -K.; Cohen-Solal, M.; Richette, P.; Branco, J.; Cancela, LeonorObjective: Hereditary hemochromatosis (HH) is a disease caused by mutations in the Hfe gene characterised by systemic iron overload and associated with an increased prevalence of osteoarthritis (OA) but the role of iron overload in the development of OA is still undefined. To further understand the molecular mechanisms involved we have used a murine model of HH and studied the progression of experimental OA und...