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Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy ...
Duarte, Ana I.; Sjögren, Marie; Santos, Maria S.; Oliveira, Catarina R.; Moreira, Paula I.; Björkqvist, MariaNeuronal loss alongside altered energy metabolism, are key features of Huntington's disease (HD) pathology. The orexigenic gut-peptide hormone ghrelin is known to stimulate appetite and affect whole body energy metabolism. Liraglutide is an efficient anti-type 2 diabetes incretin drug, with neuroprotective effects alongside anorectic properties. Combining liraglutide with the orexigenic peptide ghrelin may pote...
Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Hu...
Sjögren, Marie; Duarte, Ana I.; McCourt, Andrew C.; Shcherbina, Liliya; Wierup, Nils; Björkqvist, MariaAccumulating evidence suggests altered energy metabolism as a key feature in Huntington's disease (HD) pathology. Hyper-catabolism, including weight loss and muscle atrophy, is seen in HD patients and HD mouse models. Metabolic hormones are key players, not only in energy metabolism, but also in neurodegenerative processes. Ghrelin, a gut peptide-hormone, plays an important role in regulating energy metabolism,...