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Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activate...
Rodrigues, Fernando; Pedrosa, Jorge; Coelho, Maria Teixeira; Guedes, Joana; Ferreirinha, Pedro; Howes, Ashleigh; Lai, Wi S.; Blackshear, Perry J.The activation of TLRs by microbial molecules triggers intracellular-signaling cascades and the expression of cytokines such as IL-10. Il10 expression is tightly controlled to ensure effective immune responses, while preventing pathology. Maximal TLR-induction of Il10 transcription in macrophages requires signaling through the MAPKs, ERK, and p38. Signals via p38 downstream of TLR4 activation also regulate IL-1...
Date: 2014
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Origin: RepositóriUM - Universidade do Minho