6 documents found, page 1 of 1
Abandono y transferencia: un análisis desde la satisfacción académica en estudi...
Blanco, Elena; Tuero, Ellián; Casanova, Joana R.; Bernardo, Ana B.Para obtener un acercamiento global al abandono universitario es esencial desarrollar investigaciones centradas tanto en la transferencia (cambio de titulación y/o universidad) como en el abandono definitivo. Hasta la fecha, han aumentado el número de estudios que ahondan en las causas de este último, siendo escasos aquellos que abordan la transferencia como otra forma de abandono con graves consecuencias y alt...
Dissection of the pre-germinal center B-cell maturation pathway in common varia...
del Pino-Molina, Lucía; López-Granados, Eduardo; Lecrevisse, Quentin; Torres Canizales, Juan; Pérez-Andrés, Martín; Blanco, Elena; Wentink, MarjoleinIntroduction: Common Variable Immunodeficiency (CVID) is characterized by defective antibody production and hypogammaglobulinemia. Flow cytometry immunophenotyping of blood lymphocytes has become of great relevance for the diagnosis and classification of CVID, due to an impaired differentiation of mature post-germinal-center (GC) class-switched memory B-cells (MBC) and severely decreased plasmablast/plasma cell...
Complete Multilineage CD4 Expression Defect Associated With Warts Due to an Inh...
Fernandes, Rosa Anita; Perez-Andres, Martin; Blanco, Elena; Jara-Acevedo, Maria; Criado, Ignacio; Almeida, Julia; Botafogo, Vitor; Coutinho, InesIdiopathic T-CD4 lymphocytopenia (ICL) is a rare and heterogeneous syndrome characterized by opportunistic infections due to reduced CD4 T-lymphocytes (<300 cells/μl or <20% T-cells) in the absence of HIV infection and other primary causes of lymphopenia. Molecular testing of ICL has revealed defects in genes not specific to CD4 T-cells, with pleiotropic effects on other cell types. Here we report for the first...
Monozygotic twins concordant for common variable immunodeficiency : strikingly ...
Silva, Susana L.; Fonseca, Mariana; Pereira, Marcelo L. M.; Silva, Sara P.; Barbosa, Rita R.; Serra-Caetano, Ana; Blanco, Elena; Rosmaninho, PedroMonozygotic twins provide a unique opportunity to better understand complex genetic diseases and the relative contribution of heritable factors in shaping the immune system throughout life. Common Variable Immunodeficiency Disorders (CVID) are primary antibody defects displaying wide phenotypic and genetic heterogeneity, with monogenic transmission accounting for only a minority of the cases. Here, we report a ...
The EuroFlow PID orientation tube for flow cytometric diagnostic screening of p...
van der Burg, Mirjam; Kalina, Tomas; Perez-Andres, Martin; Vlkova, Marcela; Lopez-Granados, Eduardo; Blanco, Elena; Bonroy, Carolien; Sousa, Ana E.In the rapidly evolving field of primary immunodeficiencies (PID), the EuroFlow consortium decided to develop a PID orientation and screening tube that facilitates fast, standardized, and validated immunophenotypic diagnosis of lymphoid PID, and allows full exchange of data between centers. Our aim was to develop a tool that would be universal for all lymphoid PIDs and offer high sensitivity to identify a lymph...
Age-associated distribution of normal B-cell and plasma cell subsets in periphe...
Blanco, Elena; Pérez-Andrés, Martín; Arriba-Méndez, Sonia; Contreras-Sanfeliciano, Teresa; Criado, Ignacio; Pelak, Ondrej; Serra-Caetano, AnaBackground: Humoral immunocompetence develops stepwise throughout life and contributes to individual susceptibility to infection, immunodeficiency, autoimmunity, and neoplasia. Immunoglobulin heavy chain (IgH) isotype serum levels can partly explain such age-related differences, but their relationship with the IgH isotype distribution within memory B-cell (MBC) and plasma cell (PCs) compartments remains to be i...